A challenging redox neutral Cp*Co(III)-catalysed alkylation of acetanilides with 3-buten-2-one: synthesis and key insights into the mechanism through DFT calculations

A challenging redox neutral Cp*Co(III)-catalysed alkylation of acetanilides with 3-buten-2-one: synthesis and key insights into the mechanism through DFT calculations

Traditional, established palladium cross-coupling procedures are widely applied in complex molecule synthesis; however, there is a significant disadvantage in the requirement for pre-functionalised substrates (commonly halides/triflates). Direct C–H activation protocols provide the opportunity for a...

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Bibliographic Details
Main Authors: Andrew Kenny, Alba Pisarello, Arron Bird, Paula G. Chirila, Alex Hamilton, Christopher J. Whiteoak
Format: Article
Language:English
Published: Beilstein-Institut 2018-09-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
acetanilides
alkylation
C–H activation
cobalt catalysis
DFT studies
Online Access:https://doi.org/10.3762/bjoc.14.212

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