The Blockade of Tumoral IL1β-Mediated Signaling in Normal Colonic Fibroblasts Sensitizes Tumor Cells to Chemotherapy and Prevents Inflammatory CAF Activation

The Blockade of Tumoral IL1β-Mediated Signaling in Normal Colonic Fibroblasts Sensitizes Tumor Cells to Chemotherapy and Prevents Inflammatory CAF Activation

Heterotypic interactions between newly transformed cells and normal surrounding cells define tumor’s fate in incipient carcinomas. Once homeostasis has been lost, normal resident fibroblasts become carcinoma-associated fibroblasts, conferring protumorogenic properties on these normal cells. Here we...

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Bibliographic Details
Main Authors: Natalia Guillén Díaz-Maroto, Gemma Garcia-Vicién, Giovanna Polcaro, María Bañuls, Nerea Albert, Alberto Villanueva, David G. Molleví
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
interleukin 1 beta
tumor microenvironment
stroma
resistance
myofibroblasts
inflammatory CAFs
Online Access:https://www.mdpi.com/1422-0067/22/9/4960

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