IN VITRO INTERACTION OF INFLUENZA VIRUS A(H1N1)pdm09 WITH MONOCYTIC MACROPHAGES: INDIVIDUAL RESPONSES OF TLR7 AND RIG1 RECEPTOR GENES

IN VITRO INTERACTION OF INFLUENZA VIRUS A(H1N1)pdm09 WITH MONOCYTIC MACROPHAGES: INDIVIDUAL RESPONSES OF TLR7 AND RIG1 RECEPTOR GENES

In vitro differentiation of donor blood monocytes to macrophages (Mph) following GM-CSF treatment was accompanied by a significant increase in the levels of gene transcription signaling receptors TLR7 or RIG1. The levels of intracellular viral RNA (M1 gene) in Mph remained high upon infection by inf...

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Bibliographic Details
Main Authors: T. M. Sokolova, V. V. Poloskov, A. N. Shuvalov, I. A. Rudneva, T. A. Timofeeva
Format: Article
Language:Russian
Published: SPb RAACI 2017-12-01
Series:Medicinskaâ Immunologiâ
Subjects:
influenza virus a (h1n1)pdm09
monocytic macrophages
gene expression tlr7
rig1 receptors
Online Access:https://www.mimmun.ru/mimmun/article/view/1395

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