Tyrosine Kinase Signaling in Cancer Metabolism: PKM2 Paradox in the Warburg Effect

Tyrosine Kinase Signaling in Cancer Metabolism: PKM2 Paradox in the Warburg Effect

The Warburg Effect, or aerobic glycolysis, is one of the major metabolic alterations observed in cancer. Hypothesized to increase a cell's proliferative capacity via regenerating NAD+, increasing the pool of glycolytic biosynthetic intermediates, and increasing lactate production that affects t...

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Bibliographic Details
Main Authors: Elizabeth K. Wiese, Taro Hitosugi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
the Warburg Effect
tyrosine kinases
PKM2
lactate
pyruvate kinase
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2018.00079/full

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