Pharmacokinetic-pharmacodynamic modelling of atazanavir in hair among adolescents on antiretroviral treatment in Zimbabwe

Pharmacokinetic-pharmacodynamic modelling of atazanavir in hair among adolescents on antiretroviral treatment in Zimbabwe

Abstract Background Drug potency is a pharmacological parameter defining dose or concentration of drug required to obtain 50% of the drug’s maximal effect. Pharmacokinetic-pharmacodynamic modelling and simulation allows estimation of potency and evaluate strategies improving treatment outcome. The o...

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Bibliographic Details
Main Authors: Bernard Ngara, Simbarashe Zvada, Tariro Dianah Chawana, Charles Fungai Brian Nhachi, Simbarashe Rusakaniko
Format: Article
Language:English
Published: BMC 2021-05-01
Series:BMC Pharmacology and Toxicology
Subjects:
Pharmacodynamics
Pharmacokinetics
Modelling
HIV
Adolescents
Hair
Online Access:https://doi.org/10.1186/s40360-021-00497-8

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