Atypical presentations of celiac disease

• Main Authors: Balasa Adriana Luminita, Mihai Cristina Maria, Chisnoiu Tatiana, Frecus Corina Elena
• Format: Article
• Language: English
• Published: Sciendo 2016-08-01
• Series: ARS Medica Tomitana
• Subjects: celiac disease; children; atypical presentation
• Online Access: https://doi.org/10.1515/arsm-2016-0030

In this study we evaluated the association of celiac disease in 81 children with autoimmune disease and genetic syndromes over a two years periods (January 2014 to July 2016) in Pediatric Clinic in Constanta. Because the extraintestinal symptoms are an atypical presentation of celiac disease we determined in these children the presence of celiac disease antibodies: Anti-tissue Transglutaminase Antibody IgA and IgA total serum level as a screening method followeds in selective cases by Anti-tissue Transglutaminase Antibody IgG, anti-endomysial antibodies, deamidated gliadin antibodies IgA and IgG and intestinal biopsia. In our study 8 patients had been diagnosed with celiac disease with extraintestinal symptoms, of which 4 with type 1 diabetes, 1 patient with ataxia, 2 patients with dermatitis herpetiformis and 1 patient with Down syndrome that associate also autoimmune thyroiditis, alopecia areata, enamel hypoplasia.