Palladium on Carbon-Catalyzed Suzuki-Miyaura Coupling Reaction Using an Efficient and Continuous Flow System

Palladium on Carbon-Catalyzed Suzuki-Miyaura Coupling Reaction Using an Efficient and Continuous Flow System

The continuous flow Suzuki-Miyaura reaction between various haloarenes and arylboronic acids was successfully achieved within only ca. 20 s during the single-pass through a cartridge filled with palladium on carbon (Pd/C). No palladium leaching was observed in the collected reaction solution by ato...

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Main Authors: Tomohiro Hattori, Aya Tsubone, Yoshinari Sawama, Yasunari Monguchi, Hironao Sajiki
Format: Article
Language:English
Published: MDPI AG 2015-01-01
Series:Catalysts
Subjects:
flow reaction
ligand-free
palladium on carbon
single-pass
Suzuki-Miyaura coupling
Online Access:http://www.mdpi.com/2073-4344/5/1/18
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spelling doaj-00157de947d4419bab9864c4a2f109cb2020-11-25T00:00:36ZengMDPI AGCatalysts2073-43442015-01-0151182510.3390/catal5010018catal5010018Palladium on Carbon-Catalyzed Suzuki-Miyaura Coupling Reaction Using an Efficient and Continuous Flow SystemTomohiro Hattori0Aya Tsubone1Yoshinari Sawama2Yasunari Monguchi3Hironao Sajiki4Laboratory of Organic Chemistry, Department of Organic and Medicinal Chemistry, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, JapanLaboratory of Organic Chemistry, Department of Organic and Medicinal Chemistry, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, JapanLaboratory of Organic Chemistry, Department of Organic and Medicinal Chemistry, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, JapanLaboratory of Organic Chemistry, Department of Organic and Medicinal Chemistry, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, JapanLaboratory of Organic Chemistry, Department of Organic and Medicinal Chemistry, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, JapanThe continuous flow Suzuki-Miyaura reaction between various haloarenes and arylboronic acids was successfully achieved within only ca. 20 s during the single-pass through a cartridge filled with palladium on carbon (Pd/C). No palladium leaching was observed in the collected reaction solution by atomic absorption spectrometry (detection limit: 1 ppm).http://www.mdpi.com/2073-4344/5/1/18flow reactionligand-freepalladium on carbonsingle-passSuzuki-Miyaura coupling
collection DOAJ
language English
format Article
sources DOAJ
author Tomohiro Hattori
Aya Tsubone
Yoshinari Sawama
Yasunari Monguchi
Hironao Sajiki
spellingShingle Tomohiro Hattori
Aya Tsubone
Yoshinari Sawama
Yasunari Monguchi
Hironao Sajiki
Palladium on Carbon-Catalyzed Suzuki-Miyaura Coupling Reaction Using an Efficient and Continuous Flow System
Catalysts
flow reaction
ligand-free
palladium on carbon
single-pass
Suzuki-Miyaura coupling
author_facet Tomohiro Hattori
Aya Tsubone
Yoshinari Sawama
Yasunari Monguchi
Hironao Sajiki
author_sort Tomohiro Hattori
title Palladium on Carbon-Catalyzed Suzuki-Miyaura Coupling Reaction Using an Efficient and Continuous Flow System
title_short Palladium on Carbon-Catalyzed Suzuki-Miyaura Coupling Reaction Using an Efficient and Continuous Flow System
title_full Palladium on Carbon-Catalyzed Suzuki-Miyaura Coupling Reaction Using an Efficient and Continuous Flow System
title_fullStr Palladium on Carbon-Catalyzed Suzuki-Miyaura Coupling Reaction Using an Efficient and Continuous Flow System
title_full_unstemmed Palladium on Carbon-Catalyzed Suzuki-Miyaura Coupling Reaction Using an Efficient and Continuous Flow System
title_sort palladium on carbon-catalyzed suzuki-miyaura coupling reaction using an efficient and continuous flow system
publisher MDPI AG
series Catalysts
issn 2073-4344
publishDate 2015-01-01
description The continuous flow Suzuki-Miyaura reaction between various haloarenes and arylboronic acids was successfully achieved within only ca. 20 s during the single-pass through a cartridge filled with palladium on carbon (Pd/C). No palladium leaching was observed in the collected reaction solution by atomic absorption spectrometry (detection limit: 1 ppm).
topic flow reaction
ligand-free
palladium on carbon
single-pass
Suzuki-Miyaura coupling
url http://www.mdpi.com/2073-4344/5/1/18
work_keys_str_mv AT tomohirohattori palladiumoncarboncatalyzedsuzukimiyauracouplingreactionusinganefficientandcontinuousflowsystem
AT ayatsubone palladiumoncarboncatalyzedsuzukimiyauracouplingreactionusinganefficientandcontinuousflowsystem
AT yoshinarisawama palladiumoncarboncatalyzedsuzukimiyauracouplingreactionusinganefficientandcontinuousflowsystem
AT yasunarimonguchi palladiumoncarboncatalyzedsuzukimiyauracouplingreactionusinganefficientandcontinuousflowsystem
AT hironaosajiki palladiumoncarboncatalyzedsuzukimiyauracouplingreactionusinganefficientandcontinuousflowsystem
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