ANAT 2.0: reconstructing functional protein subnetworks

ANAT 2.0: reconstructing functional protein subnetworks

Abstract Background ANAT is a graphical, Cytoscape-based tool for the inference of protein networks that underlie a process of interest. The ANAT tool allows the user to perform network reconstruction under several scenarios in a number of organisms including yeast and human. Results Here we report...

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Bibliographic Details
Main Authors: Yomtov Almozlino, Nir Atias, Dana Silverbush, Roded Sharan
Format: Article
Language:English
Published: BMC 2017-11-01
Series:BMC Bioinformatics
Subjects:
Network inference
Protein-protein interaction network
Subnetwork reconstruction
Cytoscape plugin
Online Access:http://link.springer.com/article/10.1186/s12859-017-1932-1
Description
Summary:Abstract Background ANAT is a graphical, Cytoscape-based tool for the inference of protein networks that underlie a process of interest. The ANAT tool allows the user to perform network reconstruction under several scenarios in a number of organisms including yeast and human. Results Here we report on a new version of the tool, ANAT 2.0, which introduces substantial code and database updates as well as several new network reconstruction algorithms that greatly extend the applicability of the tool to biological data sets. Conclusions ANAT 2.0 is an up-to-date network reconstruction tool that addresses several reconstruction challenges across multiple species.
ISSN:1471-2105

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