The Fungal Cell Wall Integrity Pathway

• Format: eBook
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
• Subjects: Biology, life sciences; Research & information: general; 3D reconstruction; actomyosin ring; application; aromatic clusters; autophagy; azoles; budding yeast; CalMorph; cell cycle; cell integrity; cell integrity pathway; Cell Integrity Pathway; cell wall; cell wall integrity; cell wall integrity (CWI); cell wall integrity (CWI) pathway; cell wall integrity pathway; cell wall proteins; checkpoint; clotrimazole; conjugation; culture; CWI pathway; cysteine-rich domain; cytokinesis; detergent-free extraction; dimorphism; DNA damage; drug target; essential genes; filamentous fungi; fission yeast; fluorescence correlation spectroscopy; fungal cell wall; fungi; fungicide; glucosamine; glucose; GTPases; histidine kinase; Hrr25; hydroxyurea; hyphae; kinase assay; lysis; mannoprotein; MAP kinase; MAPK; MAPK substrate; Mec1; membrane sensor; mitogen-activated protein kinase; mitophagy; morphogenesis; morphology; Mtl1; N-glycosylation; n/a; PAN domain; Paracoccidioides; paracoccidioidomycosis; pathogenesis; phosphorylation; PKC; Pkc1; plant pathogen; ploidy; Pmk1; productivity; protein kinase C; S. japonicus; S. pombe; Saccharomyces cerevisiae; screening; septum; signaling pathway; signaling pathways; Slt2; SMALP; stress; stress response; stress tolerance; surface sensor; Tel1; transcription; transmission electron microscopy; tunicamycin; UPR; UV irradiation; virulence; Wsc1; yeast
• Online Access: Open Access: DOAB: description of the publication; Open Access: DOAB, download the publication

 Adaptation to external changes is necessary for all cells to survive and thrive in diverse environments. Key to these responses are the MAPK-mediated signaling pathways, intracellular communication routes that sense stimuli at the cell surface, and are ubiquitous in all eukaryotic organisms. In the case of fungi, MAPKs mediate essential processes, such as adaptation to environmental stresses, morphology regulation, or developmental processes. First studied in the early nineties in Saccharomyces cerevisiae, the fungal cell wall integrity (CWI) pathway has proven to be a central MAPK-mediated signaling cascade conserved in the fungal kingdom. Cells need to sense cell wall-perturbing conditions and mount the appropriate salvage response. Understanding this CWI pathway-mediated compensatory mechanism is key for the development of cell wall-targeted antifungal therapies. Moreover, its functional roles go beyond the maintenance of this essential structure, reaching many other physiological aspects that have major implications in development or virulence.In this Special Issue, expert researchers in this relevant subject have contributed with seven reviews and eleven original articles to advance our understanding of the CWI pathway by covering different structural, regulatory, and functional aspects in distinct yeasts and filamentous fungi.