Solid-Phase Microextraction and Related Techniques in Bioanalysis

• Format: eBook
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
• Subjects: Analytical chemistry; Chemistry; Research & information: general; 2-nonenal; Anacardiaceae; Aphelinus abdominalis; Aphidus colemani; aroeira; aroma; bioanalysis; biological matrices; biological properties; bladder cancer (BC); body odor; bud; cabbage; carbon materials; cerrado; Cerrado; chemoinformatics; cotinine; dioecious plant; exposure biomarkers; gas chromatography-mass spectrometry (GC-MS); GO:PANI/ZNRs/ZIF−8; green peach aphids; hair; headspace solid-phase microextraction; headspace solid-phase microextraction (HS-SPME); headspace-in needle microextraction; Herpetospermum pedunculosum; high-performance liquid chromatography; HPLC-MS; HS-SPME-GC-MS; human body odor; in-tube solid-phase microextraction; in-tube solid-phase microextraction (IT-SPME); in-tube solid-phase microextraction (SPME); liquid chromatography; liquid chromatography-tandem mass spectrometry (LC-MS/MS); mass spectrometry; metabolomics; multivariate statistical analysis; Myrtaceae; n/a; native fruit; needle-based adsorbent; nicotine; online automated analysis; parasitoids; passive smoking; pasting method; response surface methodology; Rhyzopertha dominica; risk assessment; saliva; sample preparation; sesquiterpenes; Sitophilus granarius; solid phase microextraction (SPME); solid-phase extraction; solid-phase microextraction (HS-SPME); SPME-GC-MS; stable isotope dilution; stored-product insect pests; sulfated steroid metabolites; superhydrophilic; superhydrophobic; titanium wire; tobacco-specific nitrosamines; Tribolium castaneum; urine; virtual screening; VOCs; volatile compound; volatile compounds; volatile organic compounds; volatile organic compounds (VOCs); wiping method
• Online Access: Open Access: DOAB: description of the publication; Open Access: DOAB, download the publication

 Bioanalysis of endogenous substances, metabolites, and contaminants poisons is important in analyses of biological functions, metabolomics, forensic toxicology, patient diagnosis and biomonitoring of human exposure to hazardous chemicals. In these analyses, methods of sample preparation are essential for the isolation and concentration of target analytes from complex biological matrices. These processes, however, are time-consuming, labor-intensive and error-prone, and markedly influence the reliability and accuracy of determining target analytes. Thus, efficient sample preparation techniques and their integration with analytical methods have become significant. Solid-phase microextraction (SPME) is a simple and convenient sample preparation technique that has enabled automation, miniaturization, high-throughput performance, and online coupling with analytical instruments. Moreover, SPME has reduced analysis times, as well as solvent and disposal costs.This reprint consists of 14 original, peer-reviewed papers for the Special Issue in the MDPI journal Molecules. The topics covered include headspace fiber SPME (HS-SPME) gas chromatography-mass spectrometry (GC-MS), HS-in-needle microextraction GC-MS, thin film SPME liquid chromatography-tandem mass spectrometry (LC-MS/MS), magnetic solid phase extraction LC-MS/MS, in-tube SPME LC-MS/MS and in-tube SPME LC-UV. Samples analyzed include plant-derived volatile organic compounds; body odor; metabolites in urine, plasma and saliva sample; and biomarkers of tobacco smoke exposure in hair and environmental estrogens.