The Structural and Functional Study of Efflux Pumps Belonging to the RND Transporters Family from Gram-Negative Bacteria

The Structural and Functional Study of Efflux Pumps Belonging to the RND Transporters Family from Gram-Negative Bacteria

Antimicrobial-resistant bacterial infections are a major and costly public health concern. Several pathogens are already pan-resistant, representing a major cause of mortality in patients suffering from nosocomial infections. Drug efflux pumps, which remove compounds from the bacterial cell, thereby...

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Bibliographic Details
Format: eBook
Language:English
Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
Subjects:
Biology, life sciences
Microbiology (non-medical)
Research & information: general
adaptation
Aliarcobacter butzleri
allostery
antibiotic resistance
antimicrobial resistance
assembly
conformational changes
cystic fibrosis
dominant negative effect
drug resistance
dye accumulation
efflux pump
energetic transition
evolution
gram-negative bacteria
hospital acquired infections
MdtF (YhiV)
multidrug resistance
mutation
n/a
pathogens
prevalence of efflux resistance mechanisms
protein-protein interaction
pump activation
real-time efflux
resistance
RND
RND efflux pumps
RND pump
RND-type efflux pump
virulence
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Open Access: DOAB: description of the publication
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