MicroRNA in Solid Tumor and Hematological Diseases

• Format: eBook
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
• Subjects: Research and information: general; acute lymphoblastic leukemia; acute myeloblastic leukemia; amino acid transporters; ASCT2; bladder cancer; cancer cell; cancer therapy; chemotherapy; circulating miRNAs; colorectal cancer; diagnosis; drug resistance; drug response; epithelial ovarian cancer; expression profiling; follicular lymphoma; gene expression; GI cancers; hairy cell leukemia; hepatocellular carcinoma; Hippo kinase; LAT1; liquid biopsy; liver disease; marginal zone lymphoma; microRNA; microRNAs; miR-139-3p; miR-139-5p; miR-7; miRNA; miRNAs; n/a; normal B-cell development; normalizer; ovarian cancer; paxillin (PXN); PDAC; personalized medicine; post-transcriptional regulation; primary cutaneous follicle center lymphoma; prognosis; reference miRNA; renal cell carcinoma (RCC); RT-qPCR; solid cancer; survival; targeted therapy; therapeutic target; tumor suppressor; urine; Waldenström's macroglobulinemia; Yes-associated protein
• Online Access: Open Access: DOAB: description of the publication; Open Access: DOAB, download the publication

 MicroRNAs (miRNAs), which are a type of short non-coding RNA, are involved in number of processes, such as differentiation, development, inflammation, immune response, and cancer. miRNAs, which act as oncogenes or tumor suppressor genes, can control and regulate the translation and stability of target messenger RNA, contributing to cancer pathogenesis. Despite the progress that has been made in discovering the mechanisms of how miRNAs function in tumors, many questions and aspects of miRNA biology and processing still remain to be determined. This Special Issue, titled "MicroRNA in Solid Tumor and Hematological Diseases", provides a panorama of the existing knowledge gaps and potential uses of microRNAs to predict clinical outcome or response to therapies and provides evidence to explain their role as biomarkers to modulate the biological pathways that are critical for cancer development and progression. It includes eleven peer-reviewed papers that cover the role of microRNAs in different tumor types and their potential applications in diagnosis and clinical approaches.