T Cell Differentiation and Function in Tissue Inflammation
Helper T cells play a critical role in the induction of tissue inflammation in immunity and autoimmunity. Various subsets of T cells such as Th1, Th2, Th9 and Th17 cells have been shown to play a key role in the induction of tissue inflammation in allergic and organ-specific autoimmune inflammation....
| Format: | eBook |
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| Language: | English |
| Published: |
Frontiers Media SA
2020
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| Subjects: | |
| Online Access: | Open Access: DOAB: description of the publication Open Access: DOAB, download the publication |
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| 720 | 1 | |a Awasthi, Amit |4 oth | |
| 720 | 1 | |a Goswami, Ritobrata |4 edt | |
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| 520 | |a Helper T cells play a critical role in the induction of tissue inflammation in immunity and autoimmunity. Various subsets of T cells such as Th1, Th2, Th9 and Th17 cells have been shown to play a key role in the induction of tissue inflammation in allergic and organ-specific autoimmune inflammation. On the other hand, regulatory cells such as Foxp3+Tregs and Tr1 cells are essential to control functions of effector T cells and maintain tissue homeostasis. Distinct transcriptional and molecular pathways have been identified for the generation of various effector and regulatory T cells. Emerging molecular signatures of these effectors and of regulatory T cells indicate plasticity in their developmental pathways, which is dictated by the tissue microenvironment and by other factors including cytokines and transcription factors. | ||
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| 650 | 7 | |a Medicine and Nursing |2 bicssc | |
| 653 | |a autoimmune disease | ||
| 653 | |a Cancer | ||
| 653 | |a CD4 T cell | ||
| 653 | |a CD8 T cell | ||
| 653 | |a Inflammation | ||
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