Radiopharmaceuticals for PET Imaging - Issue A

• Format: eBook
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020
• Subjects: Medicine; (S)-(−)-[18F]fluspidine; [11C]carfentanil; [18F]AlF; [18F]FACH; 18F-fluorodeoxyglucose; 18F-labeled analog of FACH; affibody molecule; AlF-radiolabelling; animal model; bioconjugation; bioorthogonal chemistry; blood-brain barrier (BBB); carfentanil; clinical outcomes; EGFR; FACH; fentanyl; fluorine-18; gallium-68; image-based internal dosimetry; imaging-based biomarker; indium-11; infection; inflammation; inverse electron-demand Diels-Alder ligation; isotopic exchange; kinetic analysis; linker; MCT1/MCT4 lactate transporter inhibitor; metabolic stability; molecular imaging; monocarboxylate transporters (MCTs); multiple myeloma; naloxone; nanobody; NODAGA; NOTA; OLINDA; opioid; orthotopic xenograft of glioblastoma in mouse; osteomyelitis; overdose; peptides; PET; PET imaging; PET radiotracers; pharmacokinetics; PODS; positron emission tomography; positron emission tomography (PET) imaging; positron emission tomography (PET), defluorination; positron emission tomography/computed tomography; preclinical development; preclinical radiopharmaceutical dosimetry; proteolysis; radiation safety; radiochemistry; radiopharmaceuticals; receptor occupancy; Siglec-9; sigma-1 receptor availability; silicon-based fluoride acceptor; single-domain antibody; small animal Positron Emission Tomography/Magnetic Resonance Imaging (PET/MRI); SPECT; Staphylococcus aureus; sub-millimetre resolution; SV2A protein; synaptic loss; tetrazine; tetrazine ligation; thiol-reactive; tumor imaging; VAP-1; vascular adhesion protein; vulnerable plaque; α-CCA
• Online Access: Open Access: DOAB: description of the publication; Open Access: DOAB, download the publication
• Physical Description: 1 online resource (212 p.)
• ISBN: 9783039432424; 9783039432431; books978-3-03943-243-1
• Access: Open Access

Positron emission tomography (PET) is a very useful technique for medical diagnosis and drug development. Radiopharmaceuticals are a key element in PET techniques and one of the pivotal factors influencing the applications of PET. The aim of this Special Issue of Molecules is to report on the recent research work on a number of aspects of PET radiopharmaceuticals and their preclinical and clinical use. More specifically, the content of this Special Issue includes but is not limited to radiolabeling design, radiosynthesis, synthesis techniques, quality control methodologies, GMP production methods, product formulation, in vitro and in vivo preclinical PET evaluations, clinical evaluations, dosimetry, stability study and metabolite analysis, and modeling.