Immunophenotyping in Autoimmune Diseases and Cancer

• Format: eBook
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020
• Subjects: Medicine; accidental cell death; Activating transcription factor 6 (ATF6); B cells; breast cancer; cancer; cancer immunology; CD180; CD8+CD28− T cells; cell therapy; chimeric antigen receptor; choriocarcinoma; citrate synthase; CpG; dcSSc; DDR; DNA topoisomerase I; flow cytometry; galectin; galectin 1; gestational trophoblastic disease; glioblastoma; Glucose-regulated protein 78 (GRP78); glycosylation; glycosylation enzymes; hydatidiform mole; IgM; IL-10; IL-6; immune cells; immunohistochemistry; immunophenotyping; immunotherapy; Inositol-requiring enzyme 1 (IRE1); lectin binding; macrophage; malignant glioma; metastatic breast cancer; myeloid-derived suppressor cells; natural autoantibodies; neuroendocrine carcinoma; neuroendocrine neoplasia; neuroendocrine tumor; non-switched B cells; oncosis; parthanatos; PKR-like endoplasmic reticulum kinase (PERK); placental-specific gene; RP105; sialylation; single cell mass cytometry; syntaxin 1; systemic lupus erythematosus; systemic sclerosis; systems biology; T cell; T cells; TLR; trastuzumab; trophoblast differentiation; tumor microenvironment; unfolded protein response
• Online Access: Open Access: DOAB: description of the publication; Open Access: DOAB, download the publication
• Physical Description: 1 online resource (170 p.)
• ISBN: 9783039434664; 9783039434671; books978-3-03943-467-1
• Access: Open Access

The cooperation of highly specialized cell types maintains the homeostasis of multicellular organisms. The disturbance of that harmony contributes to the development of several diseases. Most of the cellular functions are executed by proteins, so it is essential to investigate biological processes at the protein level. Antibodies, complex biomolecules with high specificity, are used to recognize our protein of interest in a process known as "immunophenotyping". One of the routinely used methods to study cellular proteins is flow cytometry, which detects cell surface or intracellular proteins at single-cell resolution. The other most frequent technique is the traditional immunohistochemical investigation of microscopic sections of human tissues. We called authors to publish their latest data studying cancer or autoimmune diseases by immunophenotyping.