Biomarkers of Environmental Toxicants

• Format: eBook
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020
• Subjects: Medicine and Nursing; accelerator mass spectrometry; albumin; aldehydes; aristolochic acid nephropathy; aristolochic acids; arsenic; Balkan endemic nephropathy; benzo[a]pyrene; bioinformatics; biological fluids; biomarker; biomarkers; biomonitoring; cadmium; cancer; cancer risk; carcinogen; cavity ring down spectrophotometry; cell turnover; chemical exposome; chemical toxicity; children; chronic kidney disease; codon-biased translation; data-dependent profiling; DEHP; derivatization; disease; diseases; DNA adduct bypass; DNA adducts; DNA damage; DNA lesion; DNA repair; environment; environmental monitoring; environmental pollution; epitranscriptomics; exposure biomarkers; food contamination; formalin-fixed paraffin-embedded tissues; genotoxicity; glycidol; gut microbiome; haemoglobin; hair; Hb adduct; high-resolution mass spectrometry; HPLC-MS/MS; human biomonitoring; human carcinogen; human exposure; in vivo; isotope labeling; lead; manganese; mass spectrometry; metastasis; mutagenicity; mutational signature; mutational spectrum; N-(2.3-dihydroxypropyl)valine; n/a; naphthalene; non-occupational exposure; oxidative stress; phthalate; protein adducts; radiocarbon; replication block; reproductive; root uptake; S-phenyl-mercapturic acid; shuttle vector technique; site-specific mutagenesis; stress response mechanisms; tobacco smoke; toxicity; triclocarban; tRNA modifications; UPLC/MS/MS; urine
• Online Access: Open Access: DOAB: description of the publication; Open Access: DOAB, download the publication

 Biomarkers of environmental toxicants are measures of exposures, some of which can serve to assess disease risk and inter-individual susceptibilities. Metabolites, protein and DNA adducts also serve to elucidate the mechanisms of the bioactivation and detoxication of reactive toxicant intermediates. Some environmental chemicals act as modulators of gene and protein activity, and induce the dysbiosis of the microbiome, which impacts the metabolome and overall health. In this Special Issue on "Biomarkers of Environmental Toxicants", review articles and original research studies are featured, covering the latest bioanalytical, biochemical and mass spectrometry-based technologies, to monitor exposures through targeted and non-targeted methods, and mechanistic studies that examine the biological effects of environmental toxicants in cells and humans. Diverse topics, such as exposome, microbiome, DNA/protein adducts and t-RNA modifications, as well as important environment toxicants, including heavy metals, benzene, phthalates, aldehydes, glycidol, tobacco smoke and aristolochic acids, are covered. Novel analytical methods, such as protein adductomics, DNA adduct analysis in formalin-fixed paraffin-embedded tissues, site-specific mutagenesis assay and accelerator mass spectrometry, are also included. This collection provides a valuable update of the most recent biochemical and analytical tools that employ biomarkers in toxicology research, biomarker discovery, and exposure and risk assessment in population-based studies.