Metastatic Progression and Tumour Heterogeneity

Metastatic Progression and Tumour Heterogeneity

Improved understanding of the cellular and molecular makeup of tumors in the last 30 years has unraveled a previously unexpected level of heterogeneity among tumor cells as well as within the tumor microenvironment. The concept of tumor heterogeneity underlines the realization that different tumors...

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Bibliographic Details
Format:	eBook
Language:	English
Published:	Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020
Subjects:	Medicine and Nursing 3D cultures acidosis ADH angiocrine factor beta-catenin paradox biomechanics breast cancer carbonic anhydrase cell fate cellular heterogeneity circulating tumor cells circulating tumor cells (CTCs) clear cell renal cell carcinoma clonality collective and single-cell migration colon cancer colorectal cancer CTC-clusters DCIS deficient mismatch repair EMT endometrial carcinoma epigenetics epithelial mesenchymal plasticity epithelial-to-mesenchymal transition esophageal squamous cell carcinoma extracellular vesicles gene expression genomics heterogeneity hybrid E/M hyperpolarized 13C MRI immune checkpoints immune microenvironment immunotherapy interstitial pH intra-tumour heterogeneity intratumor heterogeneity lactic acid magnetic resonance imaging mammary gland metaplastic carcinoma metastasis metastatic niche microsatellite instability miRNA expression multisite tumor sampling mutation natural killer cells nuclear medicine organoids pancreatic cancer PET phenotypic plasticity PI3K/AKT pathway plasticity positron emission tomography precision medicine radiomics radiopharmaceuticals review signaling single-cell analysis single-cell RNAseq subclonal diversity SUV target discovery targeted therapy TP53 treatment resistance tumor ecology tumor endothelial cell tumor evolution tumor heterogeneity tumor microenvironment tumor mutation burden uterine carcinosarcoma Wnt signaling
Online Access:	Open Access: DOAB: description of the publication Open Access: DOAB, download the publication

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