mTOR in Human Diseases

mTOR in Human Diseases

The mechanistic target of rapamycin (mTOR) is a major signaling intermediary that coordinates favorable environmental conditions with cell growth. Indeed, as part of two functionally distinct protein complexes, named mTORC1 and mTORC2, mTOR regulates a variety of cellular processes, including protei...

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Bibliographic Details
Format:	eBook
Language:	English
Published:	MDPI - Multidisciplinary Digital Publishing Institute 2019
Subjects:	Medicine acute myeloid leukemia advanced biliary tract cancers ageing aging AKT Alzheimer's disease AMPK anesthesia angiogenesis apoptosis autophagy biomarkers bone remodeling cancer cell signaling cellular signaling chloral hydrate combination therapy dopamine receptor eIFs Emery-Dreifuss muscular dystrophy (EDMD) epithelial to mesenchymal transition everolimus fluid shear stress fructose gluconeogenesis glucose glucose and lipid metabolism Hutchinson-Gilford progeria syndrome (HGPS) illumina immunosenescence immunotherapy inhibitor IonTorrent lamin A/C laminopathies leukemia lipid metabolism lipolysis liver male fertility MBSCs MC3T3-E1 cells Medulloblastoma melatonin metabolic diseases metabolic reprogramming metabolism methamphetamine microenvironment microRNA miRNA miRNome mTOR mTOR complex mTOR inhibitor mTOR inhibitors mTOR signal pathway mTORC1 mTORC2 n/a neurodegeneration neurodevelopment neurotoxicity NGS nocodazole nutrient sensor NVP-BEZ235 oral cavity squamous cell carcinoma (OSCC) p70S6K Parkinson's disease phosphorylation physical activity PI3K primary cilia protein aggregation proteolysis pulmonary fibrosis rapalogs rapalogues rapamycin schizophrenia senescence senolytics Sertoli cells signalling sodium iodide symporter (NIS)/SLC5A5 spermatogenesis synapse T-cell acute lymphoblastic leukemia targeted therapy therapy thyroid cancer transcriptomics tumor microenvironment tumour cachexia
Online Access:	Open Access: DOAB: description of the publication Open Access: DOAB, download the publication

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