Brain Injury and Neurodegeneration: Molecular, Functional, and Translational Approach

• Format: eBook
• Language: English
• Published: MDPI - Multidisciplinary Digital Publishing Institute 2023
• Subjects: Medicine and Nursing; Neurology and clinical neurophysiology; 18F-FDG PET; AGTPBP1; Alzheimer's disease; amyloid beta; anosmia; anti-convulsants; anti-epileptic drugs; apoptosis; blunt-force TBI; brain injury; CCP1; chronic alcoholism; cognitive impairment; CONDCA; COVID-19; drug targets; edema; epigenetics; epileptogenesis; excitotoxicity; exomiRNA; exosome; extracellular matrix; FABP3; FABP5; FABP7; gene regulation; GSK-3β; HHV-6; histone deacetylase; histone deacetylase inhibitor; hypoxia; hypoxic-ischemic injuries; icariin; icaritin; inflammation; ischemia; ischemic stroke; isomiR; mechanical stimulations; microglia; microRNA; middle cerebral artery occlusion; mild traumatic brain injury; miRNA; mitochondria; moderate traumatic brain injury; mPGES-1; n/a; natural products; neural ischemia; neural mitochondrial functions; neural tissue hypoxic injuries; neuraxis; neuro-recovery; neurodegeneration; neurodegenerative diseases; neuroinflammation; neurons; neuroprotection; neurorehabilitation; neurotrauma; NNA1; non-communicable disease; olfactory dysfunction; organelle dysfunction; oxidative stress; p-Tau; Parkinson's disease; pcd; PGE2; phytochemicals; post-traumatic seizures; pseudo-resistance; purmorphamine; reactive oxygen species; RNAseq; SARS-CoV-2; seizures; sonic hedgehog signaling; stretching; Substantia Nigra; TBI; therapeutic strategies; transcriptional modifications; traumatic brain injury; traumatic brain injury (TBI); treadmill exercise; tRNA; zebrafish
• Online Access: Open Access: DOAB: description of the publication; Open Access: DOAB, download the publication

 With the advancements in the medical and scientific fields, the global community has acquired a comprehensive understanding about brain insults and pathologies. In addition, new findings and discoveries are being made globally every day, which keep our curiosity high and drive a knowledge gain. Any brain insult or pathology is multifactorial, including a cascade of inflammation, necrotic, and apoptotic pathways; can be influenced by genetic or environmental factors; and may lead to chronic neurodegeneration or disabilities. This Special Issue, entitled "Brain Injury and Neurodegeneration: Molecular, Functional, and Translational Approach", has addressed various important aspects of brain injury and neurodegeneration, such as TBI, cerebral hypoxia, epilepsy, AD, and SARS-CoV-2-mediated brain damage. It received appreciable global response, and published 18 peer-reviewed articles, including 10 research articles and 8 reviews. Briefly, it explores the recent coronavirus infection-mediated cerebral damage; discusses the mechanism of TBI, ischemia, hypoxia, and epilepsy; talks about neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and CONDCA; and, finally, reviews the translational values of phytochemicals in brain pathologies. In conclusion, this Special Issue provides a unique review on brain injury and neurodegeneration, and will be a good tool in enhancing knowledge in terms of brain disease-related pathology, mechanisms, and translational approach.