Transcriptional Regulation and Its Misregulation in Human Diseases

• Format: eBook
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
• Subjects: Biology, life sciences; Research and information: general; 16S rRNA; adult cochlea; adult-onset asthma; aging; ALL; alternative splicing; anthrax; ATF3; Bacillus anthracis; bioinformatics; brown adipose tissue; building dampness and molds; C-type lectin; cancer; CCL1; cheA; chimeric RNAs; chronic myeloid leukemia; cold exposure; dark proteome; detection; DNA methylation; EMT; endogenous retroviruses (ERVs); endotypes; environmental intolerance; epigenetic; epigenetic biomarkers; epigenetics; FAM57A; fine tuner of cancer formation; flhDC; FOXA1; FOXP3; Fusion RNAs encoding protein; fusion transcript; GEMIN4; GGPP; GlmY; hair cells; HCC-specific small functional protein; hepatocellular carcinoma; HIF-1α; homeodomain; HOX-code; identification; lifespan; linc-223; lipid homeostasis; macropinocytosis; metabolic syndrome; metabolically healthy obesity; metastasis; miR-223 host gene; mRNA export; myeloid cell differentiation; n/a; neurodegenerative diseases; NKL-code; NONHSAT013026.2/Linc013026-68AA; NPC; NRF3; obesity; parallel reporter assay; pathobiological mechanisms; PBX1; post-translational modification; post-translational modifications; proteasome; protein homeostasis; Proteus mirabilis; QseEF; rcsB; real-time PCR; regeneration; retrotransposon; rs684232; RT-PCR; SNAI1; splicing; SVA; swarming; TALE-code; TBX-code; trans-splicing; transcription; transcription factor; transcriptional activity; transcriptional regulation; transcriptome; transcriptomics; translation; TREX; TREX-2; VPS53; XDP; YY1
• Online Access: Open Access: DOAB: description of the publication; Open Access: DOAB, download the publication
• Physical Description: 1 online resource (308 p.)
• ISBN: 9783036577364; 9783036577371; books978-3-0365-7736-4
• Access: Open Access

Transcriptional regulation is a critical biological process that allows the cell or an organism to respond to a variety of intra- and extracellular signals, to define cell identity during development, to maintain it throughout its lifetime, and to coordinate cellular activity. This control involves multiple temporal and functional steps as well as innumerable molecules including transcription factors, cofactors, and chromatin regulators. It is well known that many human disorders are characterized by global transcriptional dysregulation because most of the signaling pathways ultimately target transcription machinery. Indeed, many syndromes and genetic and complex diseases-cancer, autoimmunity, neurological and developmental disorders, and metabolic and cardiovascular diseases-can be caused by mutations/alterations in regulatory sequences, transcription factors, splicing regulators, cofactors, chromatin regulators, ncRNAs, and other components of transcription apparatus. It is worth noting that advances in our understanding of molecules and mechanisms involved in the transcriptional circuitry and apparatus lead to new insights into the pathogenetic mechanisms of various human diseases and disorders. Thus, this Special Issue is focused on molecular genetics and genomics studies exploring the effects of transcriptional misregulation on human diseases.