A preclinical orthotopic model for glioblastoma recapitulates key features of human tumors and demonstrates sensitivity to a combination of MEK and PI3K pathway inhibitors

by Rajaa El Meskini, Anthony J. Iacovelli, Alan Kulaga, Michelle Gumprecht, Philip L. Martin, Maureen Baran, Deborah B. Householder, Terry Van Dyke, Zoë Weaver Ohler
Published 2015-01-01

"Glowing head" mice: a genetic tool enabling reliable preclinical image-based evaluation of cancers in immunocompetent allografts.

by Chi-Ping Day, John Carter, Zoe Weaver Ohler, Carrie Bonomi, Rajaa El Meskini, Philip Martin, Cari Graff-Cherry, Lionel Feigenbaum, Thomas Tüting, Terry Van Dyke, Melinda Hollingshead, Glenn Merlino
Published 2014-01-01

Pathway-specific engineered mouse allograft models functionally recapitulate human serous epithelial ovarian cancer.

by Ludmila Szabova, Sujata Bupp, Muhaymin Kamal, Deborah B Householder, Lidia Hernandez, Jerome J Schlomer, Maureen L Baran, Ming Yi, Robert M Stephens, Christina M Annunziata, Philip L Martin, Terry A Van Dyke, Zoe Weaver Ohler, Simone Difilippantonio
Published 2014-01-01

Clonal Evolution and Heterogeneity of Osimertinib Acquired Resistance Mechanisms in EGFR Mutant Lung Cancer

by Nitin Roper, Anna-Leigh Brown, Jun S. Wei, Svetlana Pack, Christopher Trindade, Chul Kim, Olivia Restifo, Shaojian Gao, Sivasish Sindiri, Farid Mehrabadi, Rajaa El Meskini, Zoe Weaver Ohler, Tapan K. Maity, Abhilash Venugopalan, Constance M. Cultraro, Elizabeth Akoth, Emerson Padiernos, Haobin Chen, Aparna Kesarwala, DeeDee K. Smart, Naris Nilubol, Arun Rajan, Zofia Piotrowska, Liqiang Xi, Mark Raffeld, Anna R. Panchenko, Cenk Sahinalp, Stephen Hewitt, Chuong D. Hoang, Javed Khan, Udayan Guha
Published 2020-04-01