Animals Azoles Bagg albino mouse C57BL mouse Cigarette Smoking Humans Influenza A virus Influenza, Human Isoindoles Lung Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Organoselenium Compounds Pneumonia Pulmonary Disease, Chronic Obstructive Tobacco acute exacerbations of chronic obstructive pulmonary disease adverse event animal antioxidant cardiovascular disease chronic obstructive lung disease cigarette smoke cigarette smoking complication ebselen endothelium human