Herpes simplex virus type 1 inflammasome activation in proinflammatory human macrophages is dependent on NLRP3, ASC, and caspase-1.

by Andrew H Karaba, Alexis Figueroa, Guido Massaccesi, Sara Botto, Victor R DeFilippis, Andrea L Cox
Published 2020-01-01

The E3 Ubiquitin Ligase SIAH1 Targets MyD88 for Proteasomal Degradation During Dengue Virus Infection

by Ashleigh R. Murphy Schafer, Jessica L. Smith, Kara M. Pryke, Victor R. DeFilippis, Alec J. Hirsch
Published 2020-02-01

Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1β Protein during Virion-Mediated Activation of the AI...

by Sara Botto, Jinu Abraham, Nobuyo Mizuno, Kara Pryke, Bryan Gall, Igor Landais, Daniel N. Streblow, Klaus J. Fruh, Victor R. DeFilippis
Published 2019-02-01

Varicella Viruses Inhibit Interferon-Stimulated JAK-STAT Signaling through Multiple Mechanisms.

by Marieke C Verweij, Mary Wellish, Travis Whitmer, Daniel Malouli, Martin Lapel, Stipan Jonjić, Juergen G Haas, Victor R DeFilippis, Ravi Mahalingam, Klaus Früh
Published 2015-05-01

Chikungunya virus infection results in higher and persistent viral replication in aged rhesus macaques due to defects in anti-viral immunity.

by Ilhem Messaoudi, Jennifer Vomaske, Thomas Totonchy, Craig N Kreklywich, Kristen Haberthur, Laura Springgay, James D Brien, Michael S Diamond, Victor R Defilippis, Daniel N Streblow
Published 2013-01-01

A Herpesviral induction of RAE-1 NKG2D ligand expression occurs through release of HDAC mediated repression

by Trever T Greene, Maria Tokuyama, Giselle M Knudsen, Michele Kunz, James Lin, Alexander L Greninger, Victor R DeFilippis, Joseph L DeRisi, David H Raulet, Laurent Coscoy
Published 2016-11-01

Dysregulated TGF-β Production Underlies the Age-Related Vulnerability to Chikungunya Virus.

by Jennifer L Uhrlaub, Vesna Pulko, Victor R DeFilippis, Rebecca Broeckel, Daniel N Streblow, Gary D Coleman, Byung S Park, John F Lindo, Ivan Vickers, Joshua J Anzinger, Janko Nikolich-Žugich
Published 2016-10-01

Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses.

by Tina M Sali, Kara M Pryke, Jinu Abraham, Andrew Liu, Iris Archer, Rebecca Broeckel, Julia A Staverosky, Jessica L Smith, Ahmed Al-Shammari, Lisi Amsler, Kayla Sheridan, Aaron Nilsen, Daniel N Streblow, Victor R DeFilippis
Published 2015-12-01

Characterization of a Novel Compound That Stimulates STING-Mediated Innate Immune Activity in an Allele-Specific Manner

by Jinu Abraham, Sara Botto, Nobuyo Mizuno, Kara Pryke, Bryan Gall, Dylan Boehm, Tina M. Sali, Haihong Jin, Aaron Nilsen, Michael Gough, Jason Baird, Marita Chakhtoura, Caroline Subra, Caroline Subra, Lydie Trautmann, Elias K. Haddad, Victor R. DeFilippis
Published 2020-07-01

A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses

by Kara M. Pryke, Jinu Abraham, Tina M. Sali, Bryan J. Gall, Iris Archer, Andrew Liu, Shelly Bambina, Jason Baird, Michael Gough, Marita Chakhtoura, Elias K. Haddad, Ilsa T. Kirby, Aaron Nilsen, Daniel N. Streblow, Alec J. Hirsch, Jessica L. Smith, Victor R. DeFilippis, Terence S. Dermody
Published 2017-05-01

Correction: Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues.

by Alec J Hirsch, Jessica L Smith, Nicole N Haese, Rebecca M Broeckel, Christopher J Parkins, Craig Kreklywich, Victor R DeFilippis, Michael Denton, Patricia P Smith, William B Messer, Lois M A Colgin, Rebecca M Ducore, Peta L Grigsby, Jon D Hennebold, Tonya Swanson, Alfred W Legasse, Michael K Axthelm, Rhonda MacAllister, Clayton A Wiley, Jay A Nelson, Daniel N Streblow
Published 2017-04-01

Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues.

by Alec J Hirsch, Jessica L Smith, Nicole N Haese, Rebecca M Broeckel, Christopher J Parkins, Craig Kreklywich, Victor R DeFilippis, Michael Denton, Patricia P Smith, William B Messer, Lois M A Colgin, Rebecca M Ducore, Peta L Grigsby, Jon D Hennebold, Tonya Swanson, Alfred W Legasse, Michael K Axthelm, Rhonda MacAllister, Clayton A Wiley, Jay A Nelson, Daniel N Streblow
Published 2017-03-01