Telomere-Internal Double-Strand Breaks Are Repaired by Homologous Recombination and PARP1/Lig3-Dependent End-Joining

by Ylli Doksani, Titia de Lange
Published 2016-11-01

Characterization of t-loop formation by TRF2

by Leonid A. Timashev, Titia De Lange
Published 2020-01-01

TALEN Gene Knockouts Reveal No Requirement for the Conserved Human Shelterin Protein Rap1 in Telomere Protection and Length Regulation

by Shaheen Kabir, Dirk Hockemeyer, Titia de Lange
Published 2014-11-01

ATRX affects the repair of telomeric DSBs by promoting cohesion and a DAXX-dependent activity.

by Courtney A Lovejoy, Kaori Takai, Michael S Huh, David J Picketts, Titia de Lange
Published 2020-01-01

ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres

by Adrian S. Tong, J. Lewis Stern, Agnel Sfeir, Melissa Kartawinata, Titia de Lange, Xu-Dong Zhu, Tracy M. Bryan
Published 2015-11-01

The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response.

by Jan Karlseder, Kristina Hoke, Olga K Mirzoeva, Christopher Bakkenist, Michael B Kastan, John H J Petrini, Titia de Lange
Published 2004-08-01

Structural variant evolution after telomere crisis

by Sally M. Dewhurst, Xiaotong Yao, Joel Rosiene, Huasong Tian, Julie Behr, Nazario Bosco, Kaori K. Takai, Titia de Lange, Marcin Imieliński
Published 2021-04-01

TINF2 is a haploinsufficient tumor suppressor that limits telomere length

by Isabelle Schmutz, Arjen R Mensenkamp, Kaori K Takai, Maaike Haadsma, Liesbeth Spruijt, Richarda M de Voer, Seunga Sara Choo, Franziska K Lorbeer, Emma J van Grinsven, Dirk Hockemeyer, Marjolijn CJ Jongmans, Titia de Lange
Published 2020-12-01

Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway.

by Courtney A Lovejoy, Wendi Li, Steven Reisenweber, Supawat Thongthip, Joanne Bruno, Titia de Lange, Saurav De, John H J Petrini, Patricia A Sung, Maria Jasin, Joseph Rosenbluh, Yaara Zwang, Barbara A Weir, Charlie Hatton, Elena Ivanova, Laura Macconaill, Megan Hanna, William C Hahn, Neal F Lue, Roger R Reddel, Yuchen Jiao, Kenneth Kinzler, Bert Vogelstein, Nickolas Papadopoulos, Alan K Meeker, ALT Starr Cancer Consortium
Published 2012-01-01