Expression of the cancer-associated DNA polymerase ε P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication.

by Ignacio Soriano, Enrique Vazquez, Nagore De Leon, Sibyl Bertrand, Ellen Heitzer, Sophia Toumazou, Zhihan Bo, Claire Palles, Chen-Chun Pai, Timothy C Humphrey, Ian Tomlinson, Sue Cotterill, Stephen E Kearsey
Published 2021-07-01

SETD2-Dependent Histone H3K36 Trimethylation Is Required for Homologous Recombination Repair and Genome Stability

by Sophia X. Pfister, Sara Ahrabi, Lykourgos-Panagiotis Zalmas, Sovan Sarkar, François Aymard, Csanád Z. Bachrati, Thomas Helleday, Gaëlle Legube, Nicholas B. La Thangue, Andrew C.G. Porter, Timothy C. Humphrey
Published 2014-06-01

Set2 Methyltransferase Facilitates DNA Replication and Promotes Genotoxic Stress Responses through MBF-Dependent Transcription

by Chen-Chun Pai, Anastasiya Kishkevich, Rachel S. Deegan, Andrea Keszthelyi, Lisa Folkes, Stephen E. Kearsey, Nagore De León, Ignacio Soriano, Robertus Antonius Maria de Bruin, Antony M. Carr, Timothy C. Humphrey
Published 2017-09-01