IFNγ-Induced MHC Class II Expression on Islet Endothelial Cells Is an Early Marker of Insulitis but Is Not Required for Diabetogenic CD4+ T Cell Migration

by Nicholas A. Scott, Nicholas A. Scott, Yuxing Zhao, Balasubramanian Krishnamurthy, Balasubramanian Krishnamurthy, Stuart I. Mannering, Stuart I. Mannering, Thomas W. H. Kay, Thomas W. H. Kay, Helen E. Thomas, Helen E. Thomas
Published 2018-11-01

Tolerance to Proinsulin-1 Reduces Autoimmune Diabetes in NOD Mice

by Gaurang Jhala, Gaurang Jhala, Claudia Selck, Jonathan Chee, Jonathan Chee, Chun-Ting J. Kwong, Evan G. Pappas, Helen E. Thomas, Helen E. Thomas, Thomas W.H. Kay, Thomas W.H. Kay, Balasubramanian Krishnamurthy, Balasubramanian Krishnamurthy
Published 2021-03-01

Lipotoxic Stress Induces Pancreatic β-Cell Apoptosis through Modulation of Bcl-2 Proteins by the Ubiquitin-Proteasome System

by Sara A. Litwak, Jibran A. Wali, Evan G. Pappas, Hamdi Saadi, William J. Stanley, L. Chitra Varanasi, Thomas W. H. Kay, Helen E. Thomas, Esteban N. Gurzov
Published 2015-01-01

Loss of intra-islet heparan sulfate is a highly sensitive marker of type 1 diabetes progression in humans.

by Charmaine J Simeonovic, Sarah K Popp, Lora M Starrs, Debra J Brown, Andrew F Ziolkowski, Barbara Ludwig, Stefan R Bornstein, J Dennis Wilson, Alberto Pugliese, Thomas W H Kay, Helen E Thomas, Thomas Loudovaris, Fui Jiun Choong, Craig Freeman, Christopher R Parish
Published 2018-01-01