CardioTox net: a robust predictor for hERG channel blockade based on deep learning meta-feature ensembles

by Abdul Karim, Matthew Lee, Thomas Balle, Abdul Sattar
Published 2021-08-01

A unified model of the GABA(A) receptor comprising agonist and benzodiazepine binding sites.

by Rikke Bergmann, Kristine Kongsbak, Pernille Louise Sørensen, Tommy Sander, Thomas Balle
Published 2013-01-01

Structure-Based Discovery of Dual-Target Hits for Acetylcholinesterase and the α7 Nicotinic Acetylcholine Receptors: In Silico Studies and In Vitro Confirmation

by Sebastian Oddsson, Natalia M. Kowal, Philip K. Ahring, Elin S. Olafsdottir, Thomas Balle
Published 2020-06-01

Molecular recognition of the neurotransmitter acetylcholine by an acetylcholine binding protein reveals determinants of binding to nicotinic acetylcholine receptors.

by Jeppe A Olsen, Thomas Balle, Michael Gajhede, Philip K Ahring, Jette S Kastrup
Published 2014-01-01

Innate Immunity and Inflammation Post-Stroke: An α7-Nicotinic Agonist Perspective

by Silke Neumann, Nicholas J. Shields, Thomas Balle, Mary Chebib, Andrew N. Clarkson
Published 2015-12-01

Crystal structure of Lymnaea stagnalis AChBP complexed with the potent nAChR antagonist DHβE suggests a unique mode of antagonism.

by Azadeh Shahsavar, Jette S Kastrup, Elsebet Ø Nielsen, Jesper L Kristensen, Michael Gajhede, Thomas Balle
Published 2012-01-01

Novel Approach for the Search for Chemical Scaffolds with Activity at Both Acetylcholinesterase and the α7 Nicotinic Acetylcholine Receptor: A Perspective on Scaffolds with Dual Ac...

by Natalia M. Kowal, Dinesh C. Indurthi, Philip K. Ahring, Mary Chebib, Elin S. Olafsdottir, Thomas Balle
Published 2019-01-01

Ligand Binding at the 4-4 Agonist-Binding Site of the 42 nAChR Triggers Receptor Activation through a Pre-Activated Conformational State.

by Dinesh C Indurthi, Trevor M Lewis, Philip K Ahring, Thomas Balle, Mary Chebib, Nathan L Absalom
Published 2016-01-01