A single mutation in the envelope protein modulates flavivirus antigenicity, stability, and pathogenesis.

by Leslie Goo, Laura A VanBlargan, Kimberly A Dowd, Michael S Diamond, Theodore C Pierson
Published 2017-02-01

A dynamic landscape for antibody binding modulates antibody-mediated neutralization of West Nile virus.

by Kimberly A Dowd, Christiane A Jost, Anna P Durbin, Stephen S Whitehead, Theodore C Pierson
Published 2011-06-01

Ago-2-mediated slicer activity is essential for anti-flaviviral efficacy of RNAi.

by Shuiping Chen, Harendra S Chahar, Sojan Abraham, Haoquan Wu, Theodore C Pierson, Xiaozhong A Wang, N Manjunath
Published 2011-01-01

An mRNA Vaccine Protects Mice against Multiple Tick-Transmitted Flavivirus Infections

by Laura A. VanBlargan, Sunny Himansu, Bryant M. Foreman, Gregory D. Ebel, Theodore C. Pierson, Michael S. Diamond
Published 2018-12-01

The type-specific neutralizing antibody response elicited by a dengue vaccine candidate is focused on two amino acids of the envelope protein.

by Laura A VanBlargan, Swati Mukherjee, Kimberly A Dowd, Anna P Durbin, Stephen S Whitehead, Theodore C Pierson
Published 2013-01-01

Zika Virus Is Not Uniquely Stable at Physiological Temperatures Compared to Other Flaviviruses

by Leslie Goo, Kimberly A. Dowd, Alexander R. Y. Smith, Rebecca S. Pelc, Christina R. DeMaso, Theodore C. Pierson
Published 2016-09-01

Structural basis of differential neutralization of DENV-1 genotypes by an antibody that recognizes a cryptic epitope.

by S Kyle Austin, Kimberly A Dowd, Bimmi Shrestha, Christopher A Nelson, Melissa A Edeling, Syd Johnson, Theodore C Pierson, Michael S Diamond, Daved H Fremont
Published 2012-01-01

Maturation of West Nile virus modulates sensitivity to antibody-mediated neutralization.

by Steevenson Nelson, Christiane A Jost, Qinq Xu, Jessica Ess, Julie E Martin, Theodore Oliphant, Stephen S Whitehead, Anna P Durbin, Barney S Graham, Michael S Diamond, Theodore C Pierson
Published 2008-05-01

Inhibitors of the Histone Methyltransferases EZH2/1 Induce a Potent Antiviral State and Suppress Infection by Diverse Viral Pathogens

by Jesse H. Arbuckle, Paul J. Gardina, David N. Gordon, Heather D. Hickman, Jonathan W. Yewdell, Theodore C. Pierson, Timothy G. Myers, Thomas M. Kristie, Michael J. Imperiale
Published 2017-08-01

Potent dengue virus neutralization by a therapeutic antibody with low monovalent affinity requires bivalent engagement.

by Melissa A Edeling, S Kyle Austin, Bimmi Shrestha, Kimberly A Dowd, Swati Mukherjee, Christopher A Nelson, Syd Johnson, Manu N Mabila, Elizabeth A Christian, Joseph Rucker, Theodore C Pierson, Michael S Diamond, Daved H Fremont
Published 2014-04-01

Dengue and Zika Virus Cross-Reactive Human Monoclonal Antibodies Protect against Spondweni Virus Infection and Pathogenesis in Mice

by Vanessa Salazar, Brett W. Jagger, Juthathip Mongkolsapaya, Katherine E. Burgomaster, Wanwisa Dejnirattisai, Emma S. Winkler, Estefania Fernandez, Christopher A. Nelson, Daved H. Fremont, Theodore C. Pierson, James E. Crowe, Jr., Gavin R. Screaton, Michael S. Diamond
Published 2019-02-01

Broadly Neutralizing Activity of Zika Virus-Immune Sera Identifies a Single Viral Serotype

by Kimberly A. Dowd, Christina R. DeMaso, Rebecca S. Pelc, Scott D. Speer, Alexander R.Y. Smith, Leslie Goo, Derek J. Platt, John R. Mascola, Barney S. Graham, Mark J. Mulligan, Michael S. Diamond, Julie E. Ledgerwood, Theodore C. Pierson
Published 2016-08-01

Development of a highly protective combination monoclonal antibody therapy against Chikungunya virus.

by Pankaj Pal, Kimberly A Dowd, James D Brien, Melissa A Edeling, Sergey Gorlatov, Syd Johnson, Iris Lee, Wataru Akahata, Gary J Nabel, Mareike K S Richter, Jolanda M Smit, Daved H Fremont, Theodore C Pierson, Mark T Heise, Michael S Diamond
Published 2013-01-01

Simian Immunodeficiency Virus Infection of Rhesus Macaques Results in Delayed Zika Virus Clearance

by Carol L. Vinton, Samuel J. Magaziner, Kimberly A. Dowd, Shelly J. Robertson, Emerito Amaro-Carambot, Erik P. Karmele, Alexandra M. Ortiz, Carly E. Starke, Joseph C. Mudd, Stephen S. Whitehead, Sonja M. Best, Theodore C. Pierson, Heather D. Hickman, Jason M. Brenchley
Published 2019-12-01

A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage

by Chao Shan, Antonio E. Muruato, Brett W. Jagger, Justin Richner, Bruno T. D. Nunes, Daniele B. A. Medeiros, Xuping Xie, Jannyce G. C. Nunes, Kaitlyn M. Morabito, Wing-Pui Kong, Theodore C. Pierson, Alan D. Barrett, Scott C. Weaver, Shannan L. Rossi, Pedro F. C. Vasconcelos, Barney S. Graham, Michael S. Diamond, Pei-Yong Shi
Published 2017-09-01

Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates

by Kevin O. Saunders, Norbert Pardi, Robert Parks, Sampa Santra, Zekun Mu, Laura Sutherland, Richard Scearce, Maggie Barr, Amanda Eaton, Giovanna Hernandez, Derrick Goodman, Michael J. Hogan, Istvan Tombacz, David N. Gordon, R. Wes Rountree, Yunfei Wang, Mark G. Lewis, Theodore C. Pierson, Chris Barbosa, Ying Tam, Xiaoying Shen, Guido Ferrari, Georgia D. Tomaras, David C. Montefiori, Drew Weissman, Barton F. Haynes
Published 2021-04-01

Functional Profiling of Antibody Immune Repertoires in Convalescent Zika Virus Disease Patients

by Ahmed S. Fahad, Morgan R. Timm, Bharat Madan, Katherine E. Burgomaster, Kimberly A. Dowd, Erica Normandin, Matías F. Gutiérrez-González, Joseph M. Pennington, Matheus Oliveira De Souza, Amy R. Henry, Farida Laboune, Lingshu Wang, David R. Ambrozak, Ingelise J. Gordon, Daniel C. Douek, Julie E. Ledgerwood, Barney S. Graham, Leda R. Castilho, Theodore C. Pierson, John R. Mascola, Brandon J. DeKosky, Brandon J. DeKosky
Published 2021-02-01