Altered Gene Expression Associated with microRNA Binding Site Polymorphisms.

by Urmo Võsa, Tõnu Esko, Silva Kasela, Tarmo Annilo
Published 2015-01-01

Within-trait heterogeneity in age group differences in personality domains and facets: implications for the development and coherence of personality traits.

by René Mõttus, Anu Realo, Jüri Allik, Tõnu Esko, Andres Metspalu, Wendy Johnson
Published 2015-01-01

Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan

by Peter K. Joshi, Krista Fischer, Katharina E. Schraut, Harry Campbell, Tõnu Esko, James F. Wilson
Published 2016-03-01

Polygenic prediction of breast cancer: comparison of genetic predictors and implications for risk stratification

by Kristi Läll, Maarja Lepamets, Marili Palover, Tõnu Esko, Andres Metspalu, Neeme Tõnisson, Peeter Padrik, Reedik Mägi, Krista Fischer
Published 2019-06-01

Haplotype phasing and inheritance of copy number variants in nuclear families.

by Priit Palta, Lauris Kaplinski, Liina Nagirnaja, Andres Veidenberg, Märt Möls, Mari Nelis, Tõnu Esko, Andres Metspalu, Maris Laan, Maido Remm
Published 2015-01-01

MixFit: Methodology for Computing Ancestry-Related Genetic Scores at the Individual Level and Its Application to the Estonian and Finnish Population Studies.

by Toomas Haller, Liis Leitsalu, Krista Fischer, Marja-Liisa Nuotio, Tõnu Esko, Dorothea Irene Boomsma, Kirsten Ohm Kyvik, Tim D Spector, Markus Perola, Andres Metspalu
Published 2017-01-01

An exploratory phenome wide association study linking asthma and liver disease genetic variants to electronic health records from the Estonian Biobank.

by Glen James, Sulev Reisberg, Kaido Lepik, Nicholas Galwey, Paul Avillach, Liis Kolberg, Reedik Mägi, Tõnu Esko, Myriam Alexander, Dawn Waterworth, A Katrina Loomis, Jaak Vilo
Published 2019-01-01

Functional Impact and Evolution of a Novel Human Polymorphic Inversion That Disrupts a Gene and Creates a Fusion Transcript.

by Marta Puig, David Castellano, Lorena Pantano, Carla Giner-Delgado, David Izquierdo, Magdalena Gayà-Vidal, José Ignacio Lucas-Lledó, Tõnu Esko, Chikashi Terao, Fumihiko Matsuda, Mario Cáceres
Published 2015-10-01

The effect of X-linked dosage compensation on complex trait variation

by Julia Sidorenko, Irfahan Kassam, Kathryn E. Kemper, Jian Zeng, Luke R. Lloyd-Jones, Grant W. Montgomery, Greg Gibson, Andres Metspalu, Tonu Esko, Jian Yang, Allan F. McRae, Peter M. Visscher
Published 2019-07-01

PAIRUP-MS: Pathway analysis and imputation to relate unknowns in profiles from mass spectrometry-based metabolite data.

by Yu-Han H Hsu, Claire Churchhouse, Tune H Pers, Josep M Mercader, Andres Metspalu, Krista Fischer, Kristen Fortney, Eric K Morgen, Clicerio Gonzalez, Maria E Gonzalez, Tonu Esko, Joel N Hirschhorn
Published 2019-01-01

Pathogenic implications for autoimmune mechanisms derived by comparative eQTL analysis of CD4+ versus CD8+ T cells.

by Silva Kasela, Kai Kisand, Liina Tserel, Epp Kaleviste, Anu Remm, Krista Fischer, Tõnu Esko, Harm-Jan Westra, Benjamin P Fairfax, Seiko Makino, Julian C Knight, Lude Franke, Andres Metspalu, Pärt Peterson, Lili Milani
Published 2017-03-01

Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances

by Paul RHJ Timmers, Ninon Mounier, Kristi Lall, Krista Fischer, Zheng Ning, Xiao Feng, Andrew D Bretherick, David W Clark, eQTLGen Consortium, Xia Shen, Tõnu Esko, Zoltán Kutalik, James F Wilson, Peter K Joshi
Published 2019-01-01

Constraints on eQTL Fine Mapping in the Presence of Multisite Local Regulation of Gene Expression

by Biao Zeng, Luke R. Lloyd-Jones, Alexander Holloway, Urko M. Marigorta, Andres Metspalu, Grant W. Montgomery, Tonu Esko, Kenneth L. Brigham, Arshed A. Quyyumi, Youssef Idaghdour, Jian Yang, Peter M. Visscher, Joseph E. Powell, Greg Gibson
Published 2017-08-01

Improved polygenic prediction by Bayesian multiple regression on summary statistics

by Luke R. Lloyd-Jones, Jian Zeng, Julia Sidorenko, Loïc Yengo, Gerhard Moser, Kathryn E. Kemper, Huanwei Wang, Zhili Zheng, Reedik Magi, Tõnu Esko, Andres Metspalu, Naomi R. Wray, Michael E. Goddard, Jian Yang, Peter M. Visscher
Published 2019-11-01

Biomarker profiling by nuclear magnetic resonance spectroscopy for the prediction of all-cause mortality: an observational study of 17,345 persons.

by Krista Fischer, Johannes Kettunen, Peter Würtz, Toomas Haller, Aki S Havulinna, Antti J Kangas, Pasi Soininen, Tõnu Esko, Mari-Liis Tammesoo, Reedik Mägi, Steven Smit, Aarno Palotie, Samuli Ripatti, Veikko Salomaa, Mika Ala-Korpela, Markus Perola, Andres Metspalu
Published 2014-02-01

Reply to ‘Misestimation of heritability and prediction accuracy of male-pattern baldness’

by Nicola Pirastu, Peter K. Joshi, Paul S. de Vries, Marilyn C. Cornelis, NaNa Keum, Nora Franceschini, Marco Colombo, Edward L. Giovannucci, Athina Spiliopoulou, Lude Franke, Kari E. North, Peter Kraft, Alanna C. Morrison, Tõnu Esko, James F. Wilson
Published 2018-06-01

Human disease-associated genetic variation impacts large intergenic non-coding RNA expression.

by Vinod Kumar, Harm-Jan Westra, Juha Karjalainen, Daria V Zhernakova, Tõnu Esko, Barbara Hrdlickova, Rodrigo Almeida, Alexandra Zhernakova, Eva Reinmaa, Urmo Võsa, Marten H Hofker, Rudolf S N Fehrmann, Jingyuan Fu, Sebo Withoff, Andres Metspalu, Lude Franke, Cisca Wijmenga
Published 2013-01-01

Mediation analysis demonstrates that trans-eQTLs are often explained by cis-mediation: a genome-wide analysis among 1,800 South Asians.

by Brandon L Pierce, Lin Tong, Lin S Chen, Ronald Rahaman, Maria Argos, Farzana Jasmine, Shantanu Roy, Rachelle Paul-Brutus, Harm-Jan Westra, Lude Franke, Tonu Esko, Rakibuz Zaman, Tariqul Islam, Mahfuzar Rahman, John A Baron, Muhammad G Kibriya, Habibul Ahsan
Published 2014-12-01

Genetic regulation of spermine oxidase activity and cancer risk: a Mendelian randomization study

by João Fadista, Victor Yakimov, Urmo Võsa, Christine S. Hansen, Silva Kasela, Line Skotte, Frank Geller, Julie Courraud, Tõnu Esko, Viktorija Kukuškina, Alfonso Buil, Mads Melbye, Thomas M. Werge, David M. Hougaard, Lili Milani, Jonas Bybjerg-Grauholm, Arieh S. Cohen, Bjarke Feenstra
Published 2021-08-01

Genetic correlations reveal the shared genetic architecture of transcription in human peripheral blood

by Samuel W. Lukowski, Luke R. Lloyd-Jones, Alexander Holloway, Holger Kirsten, Gibran Hemani, Jian Yang, Kerrin Small, Jing Zhao, Andres Metspalu, Emmanouil T. Dermitzakis, Greg Gibson, Timothy D. Spector, Joachim Thiery, Markus Scholz, Grant W. Montgomery, Tonu Esko, Peter M. Visscher, Joseph E. Powell
Published 2017-09-01