Breakpoint Breakpoint uncertainty problem Breakpoints uncertainty problem Cluster Analysis Cluster analysis Clustering strategy Clusterings Constrained clustering Dissimilarity measures Genes Genome, Human Genomic Structural Variation Genomics High-Throughput Nucleotide Sequencing Humans Mendelian inheritance Mendelian inheritance error Structural variant Structural variants Uncertainty Uncertainty analysis Uncertainty problems Whole genome sequencing article cluster analysis genetic variation genomics high throughput sequencing human human genome