Dysferlin forms a dimer mediated by the C2 domains and the transmembrane domain in vitro and in living cells.

by Li Xu, Sandeep Pallikkuth, Zhanjia Hou, Gregory A Mignery, Seth L Robia, Renzhi Han
Published 2011-01-01

2-Color calcium pump reveals closure of the cytoplasmic headpiece with calcium binding.

by Zhanjia Hou, Zhihong Hu, Daniel J Blackwell, Tyler D Miller, David D Thomas, Seth L Robia
Published 2012-01-01

Defects in assembly explain reduced antiviral activity of the G249D polymorphism in human TRIM5α.

by Sevnur Kömürlü, Margret Bradley, Nikolai Smolin, Sabrina Imam, Raymond F Pauszek, Seth L Robia, David Millar, Emi E Nakayama, Tatsuo Shioda, Edward M Campbell
Published 2019-01-01

The DWORF micropeptide enhances contractility and prevents heart failure in a mouse model of dilated cardiomyopathy

by Catherine A Makarewich, Amir Z Munir, Gabriele G Schiattarella, Svetlana Bezprozvannaya, Olga N Raguimova, Ellen E Cho, Alexander H Vidal, Seth L Robia, Rhonda Bassel-Duby, Eric N Olson
Published 2018-10-01

The Ile191Val is a partial loss-of-function variant of the TAS1R2 sweet-taste receptor and is associated with reduced glucose excursions in humans

by Joan Serrano, Jaroslava Seflova, Jihye Park, Marsha Pribadi, Keisuke Sanematsu, Noriatsu Shigemura, Vanida Serna, Fanchao Yi, Andrea Mari, Erik Procko, Richard E. Pratley, Seth L. Robia, George A. Kyriazis
Published 2021-12-01

Dwarf open reading frame (DWORF) is a direct activator of the sarcoplasmic reticulum calcium pump SERCA

by M'Lynn E Fisher, Elisa Bovo, Rodrigo Aguayo-Ortiz, Ellen E Cho, Marsha P Pribadi, Michael P Dalton, Nishadh Rathod, M Joanne Lemieux, L Michel Espinoza-Fonseca, Seth L Robia, Aleksey V Zima, Howard S Young
Published 2021-06-01