The Heterooligomerization of Human Small Heat Shock Proteins Is Controlled by Conserved Motif Located in the N-Terminal Domain

by Vladislav M. Shatov, Sergei V. Strelkov, Nikolai B. Gusev
Published 2020-06-01

Dissecting the functional role of the N-terminal domain of the human small heat shock protein HSPB6.

by Michelle Heirbaut, Steven Beelen, Sergei V Strelkov, Stephen D Weeks
Published 2014-01-01

Structural Insights into the Mechanism of a Nanobody That Stabilizes PAI-1 and Modulates Its Activity

by Machteld Sillen, Stephen D. Weeks, Sergei V. Strelkov, Paul J. Declerck
Published 2020-08-01

Discovery of Novel Druggable Sites on Zika Virus NS3 Helicase Using X-ray Crystallography-Based Fragment Screening

by Ali Munawar, Steven Beelen, Ahmad Munawar, Eveline Lescrinier, Sergei V. Strelkov
Published 2018-11-01

Characterization of Mutants of Human Small Heat Shock Protein HspB1 Carrying Replacements in the N-Terminal Domain and Associated with Hereditary Motor Neuron Diseases.

by Lydia K Muranova, Stephen D Weeks, Sergei V Strelkov, Nikolai B Gusev
Published 2015-01-01

The Role of the Arginine in the Conserved N-Terminal Domain RLFDQxFG Motif of Human Small Heat Shock Proteins HspB1, HspB4, HspB5, HspB6, and HspB8

by Vladislav M. Shatov, Stephen D. Weeks, Sergei V. Strelkov, Nikolai B. Gusev
Published 2018-07-01

Structural Insight into the Two-Step Mechanism of PAI-1 Inhibition by Small Molecule TM5484

by Machteld Sillen, Toshio Miyata, Douglas E. Vaughan, Sergei V. Strelkov, Paul J. Declerck
Published 2021-02-01

Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies

by Luping Pang, Stephen D. Weeks, Martin Juhás, Sergei V. Strelkov, Jan Zitko, Arthur Van Aerschot
Published 2021-07-01

Addressing the Molecular Mechanism of Longitudinal Lamin Assembly Using Chimeric Fusions

by Giel Stalmans, Anastasia V. Lilina, Pieter-Jan Vermeire, Jan Fiala, Petr Novák, Sergei V. Strelkov
Published 2020-07-01

Molecular Interactions Driving Intermediate Filament Assembly

by Pieter-Jan Vermeire, Giel Stalmans, Anastasia V. Lilina, Jan Fiala, Petr Novak, Harald Herrmann, Sergei V. Strelkov
Published 2021-09-01

Synthesis and Biological Evaluation of 1,3-Dideazapurine-Like 7-Amino-5-Hydroxymethyl-Benzimidazole Ribonucleoside Analogues as Aminoacyl-tRNA Synthetase Inhibitors

by Baole Zhang, Luping Pang, Manesh Nautiyal, Steff De Graef, Bharat Gadakh, Eveline Lescrinier, Jef Rozenski, Sergei V. Strelkov, Stephen D. Weeks, Arthur Van Aerschot
Published 2020-10-01

Alpha-helical destabilization of the Bcl-2-BH4-domain peptide abolishes its ability to inhibit the IP3 receptor.

by Giovanni Monaco, Elke Decrock, Koen Nuyts, Larry E Wagner, Tomas Luyten, Sergei V Strelkov, Ludwig Missiaen, Wim M De Borggraeve, Luc Leybaert, David I Yule, Humbert De Smedt, Jan B Parys, Geert Bultynck
Published 2013-01-01