Synthesis of pyrrolidine-based hamamelitannin analogues as quorum sensing inhibitors in Staphylococcus aureus

by Jakob Bouton, Kristof Van Hecke, Reuven Rasooly, Serge Van Calenbergh
Published 2018-11-01

Crystal structures of bovine CD1d reveal altered αGalCer presentation and a restricted A' pocket unable to bind long-chain glycolipids.

by Jing Wang, Joren Guillaume, Nora Pauwels, Serge Van Calenbergh, Ildiko Van Rhijn, Dirk M Zajonc
Published 2012-01-01

Synthesis and structure-activity relationships of cerebroside analogues as substrates of cerebroside sulphotransferase and discovery of a competitive inhibitor

by Wenjin Li, Joren Guillaume, Younis Baqi, Isabell Wachsmann, Volkmar Gieselmann, Serge Van Calenbergh, Christa E. Müller
Published 2020-01-01

6-Methyl-7-deazapurine nucleoside analogues as broad-spectrum antikinetoplastid agents

by Cai Lin, Fabian Hulpia, Izet Karalic, Laurens De Schepper, Louis Maes, Guy Caljon, Serge Van Calenbergh
Published 2021-12-01

Design, Synthesis and Characterization of a New Series of Fluorescent Metabotropic Glutamate Receptor Type 5 Negative Allosteric Modulators

by Víctor Fernández-Dueñas, Mingcheng Qian, Josep Argerich, Carolina Amaral, Martijn D.P. Risseeuw, Serge Van Calenbergh, Francisco Ciruela
Published 2020-03-01

Structure-activity relationship of cinnamaldehyde analogs as inhibitors of AI-2 based quorum sensing and their effect on virulence of Vibrio spp.

by Gilles Brackman, Shari Celen, Ulrik Hillaert, Serge Van Calenbergh, Paul Cos, Louis Maes, Hans J Nelis, Tom Coenye
Published 2011-01-01

Synthesis of Extended Uridine Phosphonates Derived from an Allosteric P2Y2 Receptor Ligand

by Lijun Song, Martijn D. P. Risseeuw, Izet Karalic, Matthew O. Barrett, Kyle A. Brown, T. Kendall Harden, Serge Van Calenbergh
Published 2014-04-01

1-(Piperidin-3-yl)thymine amides as inhibitors of M. tuberculosis thymidylate kinase

by Yanlin Jian, Martijn D. P. Risseeuw, Mathy Froeyen, Lijun Song, Davie Cappoen, Paul Cos, Hélène Munier-Lehmann, Serge van Calenbergh
Published 2019-01-01

Synthetic Fosmidomycin Analogues with Altered Chelating Moieties Do Not Inhibit 1-Deoxy-D-xylulose 5-phosphate Reductoisomerase or Plasmodium falciparum Growth In Vitro

by René Chofor, Martijn D.P. Risseeuw, Jenny Pouyez, Chinchu Johny, Johan Wouters, Cynthia S. Dowd, Robin D. Couch, Serge Van Calenbergh
Published 2014-02-01

1-(1-Arylethylpiperidin-4-yl)thymine Analogs as Antimycobacterial TMPK Inhibitors

by Yanlin Jian, Fabian Hulpia, Martijn D. P. Risseeuw, He Eun Forbes, Guy Caljon, Hélène Munier-Lehmann, Helena I. M. Boshoff, Serge Van Calenbergh
Published 2020-06-01

Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness

by Fabian Hulpia, Dorien Mabille, Gustavo D. Campagnaro, Gabriela Schumann, Louis Maes, Isabel Roditi, Anders Hofer, Harry P. de Koning, Guy Caljon, Serge Van Calenbergh
Published 2019-12-01

Host metabolites stimulate the bacterial proton motive force to enhance the activity of aminoglycoside antibiotics.

by Aurélie Crabbé, Lisa Ostyn, Sorien Staelens, Charlotte Rigauts, Martijn Risseeuw, Maarten Dhaenens, Simon Daled, Heleen Van Acker, Dieter Deforce, Serge Van Calenbergh, Tom Coenye
Published 2019-04-01

An in silico approach for modelling T-helper polarizing iNKT cell agonists.

by Anton De Spiegeleer, Evelien Wynendaele, Matthias Vandekerckhove, Sofie Stalmans, Maxime Boucart, Nele Van Den Noortgate, Koen Venken, Serge Van Calenbergh, Sandrine Aspeslagh, Dirk Elewaut
Published 2014-01-01

4E Interacting Protein as a Potential Novel Drug Target for Nucleoside Analogues in <i>Trypanosoma Brucei</i>

by Dorien Mabille, Camila Cardoso Santos, Rik Hendrickx, Mathieu Claes, Peter Takac, Christine Clayton, Sarah Hendrickx, Fabian Hulpia, Louis Maes, Serge Van Calenbergh, Guy Caljon
Published 2021-04-01

Galactosylsphingamides: new α-GalCer analogues to probe the F’-pocket of CD1d

by Joren Guillaume, Jing Wang, Jonas Janssens, Soumya G. Remesh, Martijn D. P. Risseeuw, Tine Decruy, Mathy Froeyen, Dirk Elewaut, Dirk M. Zajonc, Serge Van Calenbergh
Published 2017-06-01

Sustainability in drug discovery

by Evelien Wynendaele, Christophe Furman, Bartosz Wielgomas, Per Larsson, Eelko Hak, Thomas Block, Serge Van Calenbergh, Nicolas Willand, Michal Markuszewski, Luke R. Odell, Gerrit J. Poelarends, Bart De Spiegeleer
Published 2021-12-01

Trapping mammalian protein complexes in viral particles

by Sven Eyckerman, Kevin Titeca, Emmy Van Quickelberghe, Eva Cloots, Annick Verhee, Noortje Samyn, Leentje De Ceuninck, Evy Timmerman, Delphine De Sutter, Sam Lievens, Serge Van Calenbergh, Kris Gevaert, Jan Tavernier
Published 2016-04-01

RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients

by Koen Venken, Peggy Jacques, Céline Mortier, Mark E. Labadia, Tine Decruy, Julie Coudenys, Kathleen Hoyt, Anita L. Wayne, Robert Hughes, Michael Turner, Sofie Van Gassen, Liesbet Martens, Dustin Smith, Christian Harcken, Joseph Wahle, Chao-Ting Wang, Eveline Verheugen, Nadia Schryvers, Gaëlle Varkas, Heleen Cypers, Ruth Wittoek, Yves Piette, Lieve Gyselbrecht, Serge Van Calenbergh, Filip Van den Bosch, Yvan Saeys, Gerald Nabozny, Dirk Elewaut
Published 2019-01-01