Nucleolar and Ribosomal Dysfunction—A Common Pathomechanism in Childhood Progerias?

by Tamara Phan, Fatima Khalid, Sebastian Iben
Published 2019-06-01

Cockayne Syndrome-Associated CSA and CSB Mutations Impair Ribosome Biogenesis, Ribosomal Protein Stability, and Global Protein Folding

by Mingyue Qiang, Fatima Khalid, Tamara Phan, Christina Ludwig, Karin Scharffetter-Kochanek, Sebastian Iben
Published 2021-06-01

Cellular sensitivity to UV-irradiation is mediated by RNA polymerase I transcription.

by Robin Assfalg, Marius Costel Alupei, Maximilian Wagner, Sylvia Koch, Omar Garcia Gonzalez, Adrian Schelling, Karin Scharffetter-Kochanek, Sebastian Iben
Published 2017-01-01

Loss of Proteostasis Is a Pathomechanism in Cockayne Syndrome

by Marius Costel Alupei, Pallab Maity, Philipp Ralf Esser, Ioanna Krikki, Francesca Tuorto, Rosanna Parlato, Marianna Penzo, Adrian Schelling, Vincent Laugel, Lorenzo Montanaro, Karin Scharffetter-Kochanek, Sebastian Iben
Published 2018-05-01

Ribosomal transcription is regulated by PGC-1alpha and disturbed in Huntington’s disease

by Sarah Jesse, Hanna Bayer, Marius C. Alupei, Martina Zügel, Medhanie Mulaw, Francesca Tuorto, Silke Malmsheimer, Karmveer Singh, Jürgen Steinacker, Uwe Schumann, Albert C. Ludolph, Karin Scharffetter-Kochanek, Anke Witting, Patrick Weydt, Sebastian Iben
Published 2017-08-01