Using Dictyostelium to Advance Our Understanding of the Role of Medium Chain Fatty Acids in Health and Disease

by Erwann Pain, Sonia Shinhmar, Robin S. B. Williams
Published 2021-09-01

All You Need Is Fats—for Seizure Control: Using Amoeba to Advance Epilepsy Research

by Eleanor C. Warren, Matthew C. Walker, Robin S. B. Williams
Published 2018-07-01

Seizure-induced reduction in PIP3 levels contributes to seizure-activity and is rescued by valproic acid

by Pishan Chang, Matthew C. Walker, Robin S.B. Williams
Published 2014-02-01

Diacylglycerol kinase (DGKA) regulates the effect of the epilepsy and bipolar disorder treatment valproic acid in Dictyostelium discoideum

by Elizabeth Kelly, Devdutt Sharma, Christopher J. Wilkinson, Robin S. B. Williams
Published 2018-09-01

Synapsin I phosphorylation is dysregulated by beta-amyloid oligomers and restored by valproic acid

by Jade Marsh, Saifuddien Haji Bagol, Robin S.B. Williams, George Dickson, Pavlos Alifragis
Published 2017-10-01

Investigating the effect of emetic compounds on chemotaxis in Dictyostelium identifies a non-sentient model for bitter and hot tastant research.

by Steven Robery, Janina Mukanowa, Nathalie Percie du Sert, Paul L R Andrews, Robin S B Williams
Published 2011-01-01

RpkA, a highly conserved GPCR with a lipid kinase domain, has a role in phagocytosis and anti-bacterial defense.

by Tanja Y Riyahi, Frederike Frese, Michael Steinert, Napoleon N Omosigho, Gernot Glöckner, Ludwig Eichinger, Benoit Orabi, Robin S B Williams, Angelika A Noegel
Published 2011-01-01

Conserved valproic-acid-induced lipid droplet formation in Dictyostelium and human hepatocytes identifies structurally active compounds

by Lucy M. Elphick, Nadine Pawolleck, Irina A. Guschina, Leila Chaieb, Daniel Eikel, Heinz Nau, John L. Harwood, Nick J. Plant, Robin S. B. Williams
Published 2012-03-01

Curcumin and derivatives function through protein phosphatase 2A and presenilin orthologues in Dictyostelium discoideum

by Marco Cocorocchio, Amy J. Baldwin, Balint Stewart, Lou Kim, Adrian J. Harwood, Christopher R. L. Thompson, Paul L. R. Andrews, Robin S. B. Williams
Published 2018-01-01

Genetic control of lithium sensitivity and regulation of inositol biosynthetic genes.

by Jason King, Melanie Keim, Regina Teo, Karin E Weening, Mridu Kapur, Karina McQuillan, Jonathan Ryves, Ben Rogers, Emma Dalton, Robin S B Williams, Adrian J Harwood
Published 2010-06-01

The antiepileptic drug valproic acid and other medium-chain fatty acids acutely reduce phosphoinositide levels independently of inositol in Dictyostelium

by Pishan Chang, Benoit Orabi, Rania M. Deranieh, Manik Dham, Oliver Hoeller, Jakob A. Shimshoni, Boris Yagen, Meir Bialer, Miriam L. Greenberg, Matthew C. Walker, Robin S. B. Williams
Published 2012-01-01

A Dictyostelium discoideum mitochondrial fluorescent tagging vector that does not affect respiratory function

by Christopher J. Perry, Eleanor C. Warren, Joseph L. Damstra-Oddy, Claire Storey, Lisa M. Francione, Sarah J. Annesley, Paul R. Fisher, Annette Müller-Taubenberger, Robin S.B. Williams
Published 2020-07-01