The US Military Commitment to Vaccine Development: A Century of Successes and Challenges

by Silvia Ratto-Kim, In-Kyu Yoon, Robert M. Paris, Jean-Louis Excler, Jerome H. Kim, Robert J. O’Connell
Published 2018-06-01

CCL3L1-CCR5 genotype improves the assessment of AIDS Risk in HIV-1-infected individuals.

by Hemant Kulkarni, Brian K Agan, Vincent C Marconi, Robert J O'Connell, Jose F Camargo, Weijing He, Judith Delmar, Kenneth R Phelps, George Crawford, Robert A Clark, Matthew J Dolan, Sunil K Ahuja
Published 2008-09-01

Accuracy of Clinical Diagnosis of Dengue Episodes in the RV144 HIV Vaccine Efficacy Trial in Thailand.

by Punnee Pitisuttithum, Supachai Rerks-Ngarm, Donald Stablein, Peter Dawson, Sorachai Nitayaphan, Jaranit Kaewkungwal, Nelson L Michael, Jerome H Kim, Merlin L Robb, Robert J O'Connell, In-Kyu Yoon, Stefan Fernandez, Jean-Louis Excler
Published 2015-01-01

HIV DNA Set Point is Rapidly Established in Acute HIV Infection and Dramatically Reduced by Early ART

by Jintanat Ananworanich, Nicolas Chomont, Leigh Ann Eller, Eugene Kroon, Sodsai Tovanabutra, Meera Bose, Martin Nau, James L.K. Fletcher, Somporn Tipsuk, Claire Vandergeeten, Robert J. O'Connell, Suteeraporn Pinyakorn, Nelson Michael, Nittaya Phanuphak, Merlin L. Robb
Published 2016-09-01

Hepatitis B vaccine antibody response and the risk of clinical AIDS or death.

by Michael L Landrum, Katherine Huppler Hullsiek, Robert J O'Connell, Helen M Chun, Anuradha Ganesan, Jason F Okulicz, Tahaniyat Lalani, Amy C Weintrob, Nancy F Crum-Cianflone, Brian K Agan, Infectious Disease Clinical Research Program HIV Working Group
Published 2012-01-01

A novel mechanism linking memory stem cells with innate immunity in protection against HIV-1 infection

by Yufei Wang, Trevor Whittall, Stuart Neil, Gary Britton, Mukesh Mistry, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Jaranit Kaewkungwal, Sorachai Nitayaphan, Xuesong Yu, Alicia Sato, Robert J. O’Connell, Nelson L. Michael, Merlin L. Robb, Jerome H. Kim, Thomas Lehner
Published 2017-04-01

Machine learning methods enable predictive modeling of antibody feature:function relationships in RV144 vaccinees.

by Ickwon Choi, Amy W Chung, Todd J Suscovich, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayaphan, Jaranit Kaewkungwal, Robert J O'Connell, Donald Francis, Merlin L Robb, Nelson L Michael, Jerome H Kim, Galit Alter, Margaret E Ackerman, Chris Bailey-Kellogg
Published 2015-04-01

Risk Factors for HIV sero-conversion in a high incidence cohort of men who have sex with men and transgender women in Bangkok, Thailand

by Tanyaporn Wansom, Sant Muangnoicharoen, Sorachai Nitayaphan, Suchai Kitsiripornchai, Trevor A. Crowell, Leilani Francisco, Paileen Gilbert, Dixion Rwakasyaguri, Jittima Dhitavat, Qun Li, David King, Merlin L. Robb, Kirsten Smith, Elizabeth A. Heger, Siriwat Akapirat, Punnee Pitisuttithum, Robert J. O'Connell, Sandhya Vasan
Published 2021-08-01

Structural analysis of the unmutated ancestor of the HIV-1 envelope V2 region antibody CH58 isolated from an RV144 vaccine efficacy trial vaccinee

by Nathan I. Nicely, Kevin Wiehe, Thomas B. Kepler, Frederick H. Jaeger, S. Moses Dennison, Supachai Rerks-Ngarm, Sorachai Nitayaphan, Punnee Pitisuttithum, Jaranit Kaewkungwal, Merlin L. Robb, Robert J. O'Connell, Nelson L. Michael, Jerome H. Kim, Hua-Xin Liao, S. Munir Alam, Kwan-Ki Hwang, Mattia Bonsignori, Barton F. Haynes
Published 2015-07-01

Characterization of HIV-1 gp120 antibody specificities induced in anogenital secretions of RV144 vaccine recipients after late boost immunizations.

by Siriwat Akapirat, Chitraporn Karnasuta, Sandhya Vasan, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sirinan Madnote, Hathairat Savadsuk, Surawach Rittiroongrad, Jiraporn Puangkaew, Sanjay Phogat, James Tartaglia, Faruk Sinangil, Mark S de Souza, Jean-Louis Excler, Jerome H Kim, Merlin L Robb, Nelson L Michael, Viseth Ngauy, Robert J O'Connell, Nicos Karasavvas, RV305 Study Group
Published 2018-01-01

An Evaluation of Selected Populations for HIV-1 Vaccine Cohort Development in Nigeria.

by Ogbonnaya S Njoku, Mark M Manak, Robert J O'Connell, Ashley L W Shutt, Jennifer A Malia, Richard A Heipertz, Sodsai Tovanabutra, Mark J Milazzo, Gideon Akindiran Akintunde, Abraham S Alabi, Aminu Suleiman, Amos A Ogundeji, Terfa S Kene, Robbie Nelson, Ojor R Ayemoba, Darrell E Singer, Merlin L Robb, Sheila A Peel, Nelson L Michael
Published 2016-01-01

Safety and reactogenicity of canarypox ALVAC-HIV (vCP1521) and HIV-1 gp120 AIDSVAX B/E vaccination in an efficacy trial in Thailand.

by Punnee Pitisuttithum, Supachai Rerks-Ngarm, Valai Bussaratid, Jittima Dhitavat, Wirach Maekanantawat, Swangjai Pungpak, Pravan Suntharasamai, Sirivan Vanijanonta, Sorachai Nitayapan, Jaranit Kaewkungwal, Michael Benenson, Patricia Morgan, Robert J O'Connell, Jeffrey Berenberg, Sanjay Gurunathan, Donald P Francis, Robert Paris, Joseph Chiu, Donald Stablein, Nelson L Michael, Jean-Louis Excler, Merlin L Robb, Jerome H Kim
Published 2011-01-01

Vaccine-induced Human Antibodies Specific for the Third Variable Region of HIV-1 gp120 Impose Immune Pressure on Infecting Viruses

by Susan Zolla-Pazner, Paul T. Edlefsen, Morgane Rolland, Xiang-Peng Kong, Allan deCamp, Raphael Gottardo, Constance Williams, Sodsai Tovanabutra, Sandra Sharpe-Cohen, James I. Mullins, Mark S. deSouza, Nicos Karasavvas, Sorachai Nitayaphan, Supachai Rerks-Ngarm, Punnee Pitisuttihum, Jaranit Kaewkungwal, Robert J. O'Connell, Merlin L. Robb, Nelson L. Michael, Jerome H. Kim, Peter Gilbert
Published 2014-11-01

V1V2-specific complement activating serum IgG as a correlate of reduced HIV-1 infection risk in RV144.

by Lautaro G Perez, David R Martinez, Allan C deCamp, Abraham Pinter, Phillip W Berman, Donald Francis, Faruk Sinangil, Carter Lee, Kelli Greene, Hongmei Gao, Sorachai Nitayaphan, Supachai Rerks-Ngarm, Jaranit Kaewkungwal, Punnee Pitisuttithum, James Tartaglia, Robert J O'Connell, Merlin L Robb, Nelson L Michael, Jerome H Kim, Peter Gilbert, David C Montefiori
Published 2017-01-01

CD8 and CD4 epitope predictions in RV144: no strong evidence of a T-cell driven sieve effect in HIV-1 breakthrough sequences from trial participants.

by Kalpana Dommaraju, Gustavo Kijak, Jonathan M Carlson, Brendan B Larsen, Sodsai Tovanabutra, Dan E Geraghty, Wenjie Deng, Brandon S Maust, Paul T Edlefsen, Eric Sanders-Buell, Silvia Ratto-Kim, Mark S deSouza, Supachai Rerks-Ngarm, Sorachai Nitayaphan, Punnee Pitisuttihum, Jaranit Kaewkungwal, Robert J O'Connell, Merlin L Robb, Nelson L Michael, James I Mullins, Jerome H Kim, Morgane Rolland
Published 2014-01-01

Antibody to HSV gD peptide induced by vaccination does not protect against HSV-2 infection in HSV-2 seronegative women.

by Peter B Gilbert, Jean-Louis Excler, Georgia D Tomaras, Lindsay N Carpp, Barton F Haynes, Hua-Xin Liao, David C Montefiori, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayaphan, Jaranit Kaewkungwal, Gustavo H Kijak, Sodsai Tovanabutra, Donald P Francis, Carter Lee, Faruk Sinangil, Phillip W Berman, Nakorn Premsri, Prayura Kunasol, Robert J O'Connell, Nelson L Michael, Merlin L Robb, Rhoda Morrow, Lawrence Corey, Jerome H Kim
Published 2017-01-01

Vaccine-induced IgG antibodies to V1V2 regions of multiple HIV-1 subtypes correlate with decreased risk of HIV-1 infection.

by Susan Zolla-Pazner, Allan deCamp, Peter B Gilbert, Constance Williams, Nicole L Yates, William T Williams, Robert Howington, Youyi Fong, Daryl E Morris, Kelly A Soderberg, Carmela Irene, Charles Reichman, Abraham Pinter, Robert Parks, Punnee Pitisuttithum, Jaranit Kaewkungwal, Supachai Rerks-Ngarm, Sorachai Nitayaphan, Charla Andrews, Robert J O'Connell, Zhi-yong Yang, Gary J Nabel, Jerome H Kim, Nelson L Michael, David C Montefiori, Hua-Xin Liao, Barton F Haynes, Georgia D Tomaras
Published 2014-01-01

Analysis of V2 antibody responses induced in vaccinees in the ALVAC/AIDSVAX HIV-1 vaccine efficacy trial.

by Susan Zolla-Pazner, Allan C deCamp, Timothy Cardozo, Nicos Karasavvas, Raphael Gottardo, Constance Williams, Daryl E Morris, Georgia Tomaras, Mangala Rao, Erik Billings, Phillip Berman, Xiaoying Shen, Charla Andrews, Robert J O'Connell, Viseth Ngauy, Sorachai Nitayaphan, Mark de Souza, Bette Korber, Richard Koup, Robert T Bailer, John R Mascola, Abraham Pinter, David Montefiori, Barton F Haynes, Merlin L Robb, Supachai Rerks-Ngarm, Nelson L Michael, Peter B Gilbert, Jerome H Kim
Published 2013-01-01

Initiation of ART during early acute HIV infection preserves mucosal Th17 function and reverses HIV-related immune activation.

by Alexandra Schuetz, Claire Deleage, Irini Sereti, Rungsun Rerknimitr, Nittaya Phanuphak, Yuwadee Phuang-Ngern, Jacob D Estes, Netanya G Sandler, Suchada Sukhumvittaya, Mary Marovich, Surat Jongrakthaitae, Siriwat Akapirat, James L K Fletscher, Eugene Kroon, Robin Dewar, Rapee Trichavaroj, Nitiya Chomchey, Daniel C Douek, Robert J O Connell, Viseth Ngauy, Merlin L Robb, Praphan Phanuphak, Nelson L Michael, Jean-Louis Excler, Jerome H Kim, Mark S de Souza, Jintanat Ananworanich, RV254/SEARCH 010 and RV304/SEARCH 013 Study Groups
Published 2014-12-01

Boosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementarity determining region in the randomized double blind RV305 HIV-1 vaccine trial.

by David Easterhoff, M Anthony Moody, Daniela Fera, Hao Cheng, Margaret Ackerman, Kevin Wiehe, Kevin O Saunders, Justin Pollara, Nathan Vandergrift, Rob Parks, Jerome Kim, Nelson L Michael, Robert J O'Connell, Jean-Louis Excler, Merlin L Robb, Sandhya Vasan, Supachai Rerks-Ngarm, Jaranit Kaewkungwal, Punnee Pitisuttithum, Sorachai Nitayaphan, Faruk Sinangil, James Tartaglia, Sanjay Phogat, Thomas B Kepler, S Munir Alam, Hua-Xin Liao, Guido Ferrari, Michael S Seaman, David C Montefiori, Georgia D Tomaras, Stephen C Harrison, Barton F Haynes
Published 2017-02-01