Algorithms Background signals Bias ChIP-seq Chromatin Immunoprecipitation Chromatin Immunoprecipitation Sequencing Chromatin immunoprecipitation Controls DNA sequence High-Throughput Nucleotide Sequencing High-throughput sequencing Histone modification Least squares regression Noise distribution Reproducibilities Reproducibility of Results Scientific community Sequence Analysis, DNA algorithm article chromatin immunoprecipitation chromatin immunoprecipitation sequencing controlled study high throughput sequencing histone modification least square analysis noise reliability reproducibility