In Silico HCT116 Human Colon Cancer Cell-Based Models En Route to the Discovery of Lead-Like Anticancer Drugs

by Sara Cruz, Sofia E. Gomes, Pedro M. Borralho, Cecília M. P. Rodrigues, Susana P. Gaudêncio, Florbela Pereira
Published 2018-07-01

Convergence of miR-143 overexpression, oxidative stress and cell death in HCT116 human colon cancer cells.

by Sofia E Gomes, Diane M Pereira, Catarina Roma-Rodrigues, Alexandra R Fernandes, Pedro M Borralho, Cecília M P Rodrigues
Published 2018-01-01

miR-143 overexpression impairs growth of human colon carcinoma xenografts in mice with induction of apoptosis and inhibition of proliferation.

by Pedro M Borralho, André E S Simões, Sofia E Gomes, Raquel T Lima, Tânia Carvalho, Duarte M S Ferreira, Maria H Vasconcelos, Rui E Castro, Cecília M P Rodrigues
Published 2011-01-01

Targeting KRAS Oncogene in Colon Cancer Cells with 7-Carboxylate Indolo[3,2-b]quinoline Tri-Alkylamine Derivatives.

by Hugo Brito, Ana Cláudia Martins, João Lavrado, Eduarda Mendes, Ana Paula Francisco, Sofia A Santos, Stephan A Ohnmacht, Nam-Soon Kim, Cecília M P Rodrigues, Rui Moreira, Stephen Neidle, Pedro M Borralho, Alexandra Paulo
Published 2015-01-01

miRNA expression in colon polyps provides evidence for a multihit model of colon cancer.

by Ann L Oberg, Amy J French, Aaron L Sarver, Subbaya Subramanian, Bruce W Morlan, Shaun M Riska, Pedro M Borralho, Julie M Cunningham, Lisa A Boardman, Liang Wang, Thomas C Smyrk, Yan Asmann, Clifford J Steer, Stephen N Thibodeau
Published 2011-01-01