Catalytic inhibitors of topoisomerase II differently modulate the toxicity of anthracyclines in cardiac and cancer cells.

by Anna Vavrova, Hana Jansova, Eliska Mackova, Miloslav Machacek, Pavlina Haskova, Lucie Tichotova, Martin Sterba, Tomas Simunek
Published 2013-01-01

Quantitative analysis of the anti-proliferative activity of combinations of selected iron-chelating agents and clinically used anti-neoplastic drugs.

by Eliska Potuckova, Hana Jansova, Miloslav Machacek, Anna Vavrova, Pavlina Haskova, Lucie Tichotova, Vera Richardson, Danuta S Kalinowski, Des R Richardson, Tomas Simunek
Published 2014-01-01

Cucurbitacin E Has Neuroprotective Properties and Autophagic Modulating Activities on Dopaminergic Neurons

by Anne-Marie Arel-Dubeau, Fanny Longpré, Julie Bournival, Cindy Tremblay, Julie Demers-Lamarche, Pavlina Haskova, Everaldo Attard, Marc Germain, Maria-Grazia Martinoli
Published 2014-01-01

Protective Effects of D-Penicillamine on Catecholamine-Induced Myocardial Injury

by Michal Říha, Pavlína Hašková, Jan Martin, Tomáš Filipský, Kateřina Váňová, Jaroslava Vávrová, Magdalena Holečková, Pavel Homola, Libor Vítek, Vladimír Palicka, Tomáš Šimůnek, Přemysl Mladěnka
Published 2016-01-01

In Vitro Characterization of the Pharmacological Properties of the Anti-Cancer Chelator, Bp4eT, and Its Phase I Metabolites.

by Eliška Potůčková, Jaroslav Roh, Miloslav Macháček, Sumit Sahni, Ján Stariat, Vít Šesták, Hana Jansová, Pavlína Hašková, Anna Jirkovská, Kateřina Vávrová, Petra Kovaříková, Danuta S Kalinowski, Des R Richardson, Tomáš Šimůnek
Published 2015-01-01

Structure-activity relationships of novel salicylaldehyde isonicotinoyl hydrazone (SIH) analogs: iron chelation, anti-oxidant and cytotoxic properties.

by Eliška Potůčková, Kateřina Hrušková, Jan Bureš, Petra Kovaříková, Iva A Špirková, Kateřina Pravdíková, Lucie Kolbabová, Tereza Hergeselová, Pavlína Hašková, Hana Jansová, Miloslav Macháček, Anna Jirkovská, Vera Richardson, Darius J R Lane, Danuta S Kalinowski, Des R Richardson, Kateřina Vávrová, Tomáš Šimůnek
Published 2014-01-01