Early changes of neuromuscular transmission in the SOD1(G93A) mice model of ALS start long before motor symptoms onset.

by Mariana C Rocha, Paula A Pousinha, Alexandra M Correia, Ana M Sebastião, Joaquim A Ribeiro
Published 2013-01-01

Adenosine A2A receptors activation facilitates neuromuscular transmission in the pre-symptomatic phase of the SOD1(G93A) ALS mice, but not in the symptomatic phase.

by Filipe Nascimento, Paula A Pousinha, Alexandra M Correia, Rui Gomes, Ana M Sebastião, Joaquim A Ribeiro
Published 2014-01-01

Physiological and pathophysiological control of synaptic GluN2B-NMDA receptors by the C-terminal domain of amyloid precursor protein

by Paula A Pousinha, Xavier Mouska, Elisabeth F Raymond, Carole Gwizdek, Gihen Dhib, Gwenola Poupon, Laure-Emmanuelle Zaragosi, Camilla Giudici, Ingrid Bethus, Emilie Pacary, Michael Willem, Hélène Marie
Published 2017-07-01

Aη-α and Aη-β peptides impair LTP ex vivo within the low nanomolar range and impact neuronal activity in vivo

by Maria Mensch, Jade Dunot, Sandy M. Yishan, Samuel S. Harris, Aline Blistein, Alban Avdiu, Paula A. Pousinha, Camilla Giudici, Marc Aurel Busche, Peter Jedlicka, Michael Willem, Hélène Marie
Published 2021-07-01

A two-hit story: Seizures and genetic mutation interaction sets phenotype severity in SCN1A epilepsies

by Ana Rita Salgueiro-Pereira, Fabrice Duprat, Paula A. Pousinha, Alexandre Loucif, Vincent Douchamps, Cristina Regondi, Marion Ayrault, Martine Eugie, Marion I. Stunault, Andrew Escayg, Romain Goutagny, Vadym Gnatkovsky, Carolina Frassoni, Hélène Marie, Ingrid Bethus, Massimo Mantegazza
Published 2019-05-01

The Amyloid Precursor Protein C-Terminal Domain Alters CA1 Neuron Firing, Modifying Hippocampus Oscillations and Impairing Spatial Memory Encoding

by Paula A. Pousinha, Xavier Mouska, Daniela Bianchi, Mariana Temido-Ferreira, Joana Rajão-Saraiva, Rui Gomes, Sebastian P. Fernandez, Ana Rita Salgueiro-Pereira, Carine Gandin, Elisabeth F. Raymond, Jacques Barik, Romain Goutagny, Ingrid Bethus, Luisa V. Lopes, Michele Migliore, Hélène Marie
Published 2019-10-01