The Challenge of Interpreting Alanine Aminotransferase Elevations in Clinical Trials of New Drug Candidates

by Rachel J. Church, Paul B. Watkins
Published 2021-03-01

Precision Dosing Priority Criteria: Drug, Disease, and Patient Population Variables

by Rachel J. Tyson, Christine C. Park, J. Robert Powell, J. Herbert Patterson, Daniel Weiner, Paul B. Watkins, Paul B. Watkins, Daniel Gonzalez
Published 2020-04-01

Bioprinted liver provides early insight into the role of Kupffer cells in TGF-β1 and methotrexate-induced fibrogenesis.

by Leah M Norona, Deborah G Nguyen, David A Gerber, Sharon C Presnell, Merrie Mosedale, Paul B Watkins
Published 2019-01-01

Glutamate dehydrogenase as a biomarker for mitotoxicity; insights from furosemide hepatotoxicity in the mouse.

by Rachel J Church, Shelli J Schomaker, J Scott Eaddy, Germaine G Boucher, John M Kreeger, Jiri Aubrecht, Paul B Watkins
Published 2020-01-01

Cytochromes P450 are Expressed in Proliferating Cells in Barrett's Metaplasia

by Steven J. Hughes, Mark A. Morse, Christopher M. Weghorst, Hyesook Kim, Paul B. Watkins, F. Peter Guengerich, Mark B. Orringer, David G. Beer
Published 1999-06-01

Genetic Polymorphisms Implicated in Nonalcoholic Liver Disease or Selected Other Disorders Have No Influence on Drug‐Induced Liver Injury

by Herbert L. Bonkovsky, Tyler Severson, Paola Nicoletti, Huiman Barnhart, Jose Serrano, Naga Chalasani, Robert J. Fontana, Paul B. Watkins, Victor Navarro, Andrew Stolz, Ann K. Daly, Guruparasad P. Aithal, Joseph Odin, the US DILIN Investigators
Published 2019-08-01

Quantitative systems toxicology (QST) reproduces species differences in PF‐04895162 liver safety due to combined mitochondrial and bile acid toxicity

by Grant Generaux, Vinal V. Lakhani, Yuching Yang, Sashi Nadanaciva, Luping Qiu, Keith Riccardi, Li Di, Brett A. Howell, Scott Q. Siler, Paul B. Watkins, Hugh A. Barton, Michael D. Aleo, Lisl K. M. Shoda
Published 2019-12-01

Modeling drug- and chemical- induced hepatotoxicity with systems biology approaches

by Sudin eBhattacharya, Lisl K.M. Shoda, Qiang eZhang, Courtney eWoods, Brett A. Howell, Scott Q. Siler, Jeffrey L. Woodhead, Yuching eYang, Patrick eMcMullen, Paul B. Watkins, Melvin E. Andersen
Published 2012-12-01

Correction: Cytokine profiles in acute liver injury-Results from the US Drug-Induced Liver Injury Network (DILIN) and the Acute Liver Failure Study Group.

by Herbert L Bonkovsky, Huiman X Barnhart, David M Foureau, Nury Steuerwald, William M Lee, Jiezhun Gu, Robert J Fontana, Paul H Hayashi, Naga Chalasani, Victor M Navarro, Joseph Odin, Andrew Stolz, Paul B Watkins, Jose Serrano, US Drug-Induced Liver Injury Network and the Acute Liver Failure Study Group
Published 2019-01-01

Cytokine profiles in acute liver injury-Results from the US Drug-Induced Liver Injury Network (DILIN) and the Acute Liver Failure Study Group.

by Herbert L Bonkovsky, Huiman X Barnhart, David M Foureau, Nury Steuerwald, William M Lee, Jiezhun Gu, Robert J Fontana, Paul J Hayashi, Naga Chalasani, Victor M Navarro, Joseph Odin, Andrew Stolz, Paul B Watkins, Jose Serrano, US Drug-Induced Liver Injury Network and the Acute Liver Failure Study Group
Published 2018-01-01

Profiles of serum cytokines in acute drug-induced liver injury and their prognostic significance.

by Nury M Steuerwald, David M Foureau, H James Norton, Jie Zhou, Judith C Parsons, Naga Chalasani, Robert J Fontana, Paul B Watkins, William M Lee, K Rajender Reddy, Andrew Stolz, Jayant Talwalkar, Timothy Davern, Dhanonjoy Saha, Lauren N Bell, Huiman Barnhart, Jiezhun Gu, Jose Serrano, Herbert L Bonkovsky
Published 2013-01-01