Adult Article Beck Depression Inventory Bipolar Disorder Depression Depressive Disorder, Major Diagnostic and Statistical Manual of Mental Disorders Excitatory Amino Acid Antagonists Female Growth mixture modeling Hamilton Depression Rating Scale Humans Ketamine Logistic Models Male Middle Aged Montgomery Asberg Depression Rating Scale Psychiatric Status Rating Scales Suicidal Ideation Suicidal ideation Suicide adult amino acid receptor blocking agent automutilation biological marker bipolar I disorder bipolar II disorder bipolar depression bipolar disorder crossover procedure