TCR signaling emerges from the sum of many parts.

by Michael S Kuhns, Mark M Davis
Published 2012-06-01

Self-recognition drives the preferential accumulation of promiscuous CD4+ T-cells in aged mice

by Neha R Deshpande, Heather L Parrish, Michael S Kuhns
Published 2015-07-01

Reciprocal TCR-CD3 and CD4 Engagement of a Nucleating pMHCII Stabilizes a Functional Receptor Macrocomplex

by Caleb R. Glassman, Heather L. Parrish, Mark S. Lee, Michael S. Kuhns
Published 2018-01-01

A disconnect between precursor frequency, expansion potential, and site-specific CD4+ T cell responses in aged mice.

by Neha R Deshpande, Jennifer L Uhrlaub, Sing Sing Way, Janko Nikolich-Žugich, Michael S Kuhns
Published 2018-01-01

Correction: A Transmembrane Domain GGxxG Motif in CD4 Contributes to Its Lck-Independent Function but Does Not Mediate CD4 Dimerization.

by Heather L Parrish, Caleb R Glassman, Madeline M Keenen, Neha R Deshpande, Matthew P Bronnimann, Michael S Kuhns
Published 2016-01-01

A Transmembrane Domain GGxxG Motif in CD4 Contributes to Its Lck-Independent Function but Does Not Mediate CD4 Dimerization.

by Heather L Parrish, Caleb R Glassman, Madeline M Keenen, Neha R Deshpande, Matthew P Bronnimann, Michael S Kuhns
Published 2015-01-01

Domain-swapped T cell receptors improve the safety of TCR gene therapy

by Michael T Bethune, Marvin H Gee, Mario Bunse, Mark S Lee, Eric H Gschweng, Meghana S Pagadala, Jing Zhou, Donghui Cheng, James R Heath, Donald B Kohn, Michael S Kuhns, Wolfgang Uckert, David Baltimore
Published 2016-11-01