Regulation and Dysregulation of Chromosome Structure in Cancer

by Hnisz, Denes, Schuijers, Jurian, Li, Charles Han, Young, Richard A.
Published 2018

Mediator and RNA polymerase II clusters associate in transcription-dependent condensates

by Cho, Won-ki, Spille, Jan Hendrik, Hecht, Micca, Lee, Choongman, Li, Charles Han, Grube, Valentin, Cisse, Ibrahim I
Published 2020

Parallel Automated Flow Synthesis of Covalent Protein Complexes That Can Inhibit MYC-Driven Transcription

by Pomplun, Sebastian, Jbara, Muhammad, Schissel, Carly K, Wilson Hawken, Susana, Boija, Ann, Li, Charles, Klein, Isaac, Pentelute, Bradley L
Published 2022

Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene

by Liu, X. Shawn, Wu, Hao, Krzisch, Marine, Wu, Xuebing, Graef, John, Muffat, Julien, Hnisz, Denes, Li, Charles Han, Yuan, Bingbing, Xu, Chuanyun, Li, Yun, Vershkov, Dan, Cacace, Angela, Young, Richard A., Jaenisch, Rudolf
Published 2020

Small genomic insertions form enhancers that misregulate oncogenes

by Hnisz, Denes, Li, Zhaodong, Weichert-Leahey, Nina, Rahman, Sunniyat, Liu, Yu, Etchin, Julia, Li, Benshang, Shen, Shuhong, Zhang, Jinghui, Look, A. Thomas, Mansour, Marc R., Abraham, Brian Joseph, Weintraub, Abraham Selby, Kwiatkowski, Nick, Li, Charles Han, Lee, Tong Ihn, Young, Richard A.
Published 2017

Activation of proto-oncogenes by disruption of chromosome neighborhoods

by Hnisz, D., Day, D. S., Valton, A.-L, Bak, R. O., Goldmann, J., Lajoie, B. R., Sigova, A. A., Lee, T. I., Porteus, M. H., Dekker, J., Weintraub, Abraham Selby, Li, Charles Han, Reddy, Jessica, Borges-Rivera, Diego Ramon, Jaenisch, Rudolf, Fan, Zi Peng, Young, Richard A.
Published 2017

YY1 Is a Structural Regulator of Enhancer-Promoter Loops

by Sigova, Alla A., Hannett, Nancy M., Day, Daniel S., Abraham, Brian J., Cohen, Malkiel A., Nabet, Behnam, Buckley, Dennis L., Guo, Yang Eric, Hnisz, Denes, Bradner, James E., Gray, Nathanael S., Weintraub, Abraham Selby, Li, Charles Han, Zamudio Montes de Oca, Alicia, Jaenisch, Rudolf, Young, Richard A.
Published 2018

Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains

by Klein, Isaac A., Sabari, Benjamin R., Dall'Agnese, Alessandra, Coffey, Eliot L., Zamudio, Alicia V., Manteiga, John C., Hannett, Nancy M., Abraham, Brian J., Afeyan, Lena K., Guo, Yang E., Schuijers, Jurian, Lee, Tong Ihn, Taatjes, Dylan J., Young, Richard A., Shrinivas, Krishna,Ph. D.Massachusetts Institute of Technology, Li, Charles H.
Published 2020

Coactivator condensation at super-enhancers links phase separation and gene control

by Sabari, Benjamin R., Dall'Agnese, Alessandra, Boija, Ann, Klein, Isaac A., Abraham, Brian J., Hannett, Nancy M., Guo, Yang E., Day, Daniel S., Schuijers, Jurian, Hnisz, Denes, Lee, Tong Ihn, Coffey, Eliot Leo, Shrinivas, Krishna, Zamudio Montes de Oca, Alicia, Manteiga, John Colonnese, Li, Charles Han, Vasile, Eliza, Cisse, Ibrahim I, Chakraborty, Arup K, Sharp, Phillip A., Young, Richard A.
Published 2019

Mediator Condensates Localize Signaling Factors to Key Cell Identity Genes

by Zamudio Montes de Oca, Alicia, Dall'Agnese, Alessandra, Henninger, Jonathan E., Manteiga, John Colonnese, Afeyan, Lena K., Hannett, Nancy M., Coffey, Eliot Leo, Li, Charles Han, Oksuz, Ozgur, Sabari, Benjamin R., Boija, Ann, Klein, Isaac A., Hawken, Susana W, Spille, Jan Hendrik, Cisse, Ibrahim I, Abraham, Brian Joseph, Lee, Tong Ihn, Taatjes, Dylan J., Schuijers, Jurian, Young, Richard A.
Published 2021