SIR2 Proteins Regulate Aging in Response to Nutrients

by Leonard Guarente
Published 2001-01-01

Increased life span due to calorie restriction in respiratory-deficient yeast.

by Su-Ju Lin, Leonard Guarente
Published 2006-03-01

SIRT1 is a positive regulator of the master osteoblast transcription factor, RUNX2.

by Kayvan Zainabadi, Cassie J Liu, Leonard Guarente
Published 2017-01-01

Correction: SIRT2 Ablation Has No Effect on Tubulin Acetylation in Brain, Cholesterol Biosynthesis or the Progression of Huntington's Disease Phenotypes In Vivo.

by Anna Bobrowska, Gizem Donmez, Andreas Weiss, Leonard Guarente, Gillian Bates
Published 2021-01-01

SIRT2 ablation has no effect on tubulin acetylation in brain, cholesterol biosynthesis or the progression of Huntington's disease phenotypes in vivo.

by Anna Bobrowska, Gizem Donmez, Andreas Weiss, Leonard Guarente, Gillian Bates
Published 2012-01-01

SIRT1 is a positive regulator of in vivo bone mass and a therapeutic target for osteoporosis.

by Kayvan Zainabadi, Cassie J Liu, Alison L M Caldwell, Leonard Guarente
Published 2017-01-01

Muscle-specific SIRT1 gain-of-function increases slow-twitch fibers and ameliorates pathophysiology in a mouse model of duchenne muscular dystrophy.

by Angeliki Chalkiadaki, Masaki Igarashi, Armiyaw Sebastian Nasamu, Jovana Knezevic, Leonard Guarente
Published 2014-07-01

Mutations that Allow SIR2 Orthologs to Function in a NAD+-Depleted Environment

by Caitlin R. Ondracek, Vincent Frappier, Alison E. Ringel, Cynthia Wolberger, Leonard Guarente
Published 2017-03-01

SIRT1 Suppresses the Epithelial-to-Mesenchymal Transition in Cancer Metastasis and Organ Fibrosis

by Petra Simic, Eric O. Williams, Eric L. Bell, Jing Jing Gong, Michael Bonkowski, Leonard Guarente
Published 2013-04-01

Caloric restriction blocks neuropathology and motor deficits in Machado–Joseph disease mouse models through SIRT1 pathway

by Janete Cunha-Santos, Joana Duarte-Neves, Vitor Carmona, Leonard Guarente, Luís Pereira de Almeida, Cláudia Cavadas
Published 2016-05-01

Sirtuin 1 Promotes Deacetylation of Oct4 and Maintenance of Naive Pluripotency

by Eric O. Williams, Amy K. Taylor, Eric L. Bell, Rachelle Lim, Daniel M. Kim, Leonard Guarente
Published 2016-10-01

Author Correction: Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled...

by Ryan W. Dellinger, Santiago Roel Santos, Mark Morris, Mal Evans, Dan Alminana, Leonard Guarente, Eric Marcotulli
Published 2018-08-01

Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study

by Ryan W. Dellinger, Santiago Roel Santos, Mark Morris, Mal Evans, Dan Alminana, Leonard Guarente, Eric Marcotulli
Published 2017-11-01

Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection.

by Laura E Crotty Alexander, Brenda J Marsh, Anjuli M Timmer, Ann E Lin, Kayvan Zainabadi, Agnieszka Czopik, Leonard Guarente, Victor Nizet
Published 2013-01-01

Correction: Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic ß Cells.

by Laura Bordone, Maria Carla Motta, Frederic Picard, Ashley Robinson, Ulupi S Jhala, Javier Apfeld, Thomas McDonagh, Madeleine Lemieux, Michael McBurney, Akos Szilvasi, Erin J Easlon, Su-Ju Lin, Leonard Guarente
Published 2006-09-01

Correction: Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells.

by Laura Bordone, Maria Carla Motta, Frederic Picard, Ashley Robinson, Ulupi S Jhala, Javier Apfeld, Thomas McDonagh, Madeleine Lemieux, Michael McBurney, Akos Szilvasi, Erin J Easlon, Su-Ju Lin, Leonard Guarente
Published 2015-12-01

Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells.

by Laura Bordone, Maria Carla Motta, Frederic Picard, Ashley Robinson, Ulupi S Jhala, Javier Apfeld, Thomas McDonagh, Madeleine Lemieux, Michael McBurney, Akos Szilvasi, Erin J Easlon, Su-Ju Lin, Leonard Guarente
Published 2006-02-01

SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kgamma Activity through Deacetylation of Specific Lysine Residues in Mammals.

by Sayaka Akieda-Asai, Nobuhiro Zaima, Koji Ikegami, Tomoaki Kahyo, Ikuko Yao, Takahiro Hatanaka, Shun-Ichiro Iemura, Rika Sugiyama, Takeaki Yokozeki, Yoshinobu Eishi, Morio Koike, Kyoji Ikeda, Takuya Chiba, Haruyoshi Yamaza, Isao Shimokawa, Si-Young Song, Akira Matsuno, Akiko Mizutani, Motoji Sawabe, Moses V Chao, Masashi Tanaka, Yasunori Kanaho, Tohru Natsume, Haruhiko Sugimura, Yukari Date, Michael W McBurney, Leonard Guarente, Mitsutoshi Setou
Published 2010-01-01

Genetic analysis of longevity in Saccharomyces cerevisiae

by Kaeberlein, Matt (Matt Robert), 1971-
Published 2005

Genetic regulation of dietary restriction-induced longevity in Caenorhabditis elegans

by Bishop, Nicholas A
Published 2007