IL-2 suppression of IL-12p70 by a recombinant HSV-1 expressing IL-2 induces T-cell auto-reactivity and CNS demyelination.

by Mandana Zandian, Kevin R Mott, Sariah J Allen, Shuang Chen, Moshe Arditi, Homayon Ghiasi
Published 2011-02-01

Binding of HSV-1 glycoprotein K (gK) to signal peptide peptidase (SPP) is required for virus infectivity.

by Sariah J Allen, Kevin R Mott, Yoshiharu Matsuura, Kohji Moriishi, Konstantin G Kousoulas, Homayon Ghiasi
Published 2014-01-01

Suppression of IL-12p70 formation by IL-2 or following macrophage depletion causes T-cell autoreactivity leading to CNS demyelination in HSV-1-infected mice.

by Dhong Hyun Lee, Mandana Zandian, Jane Kuo, Kevin R Mott, Shuang Chen, Moshe Arditi, Homayon Ghiasi
Published 2017-05-01

Identification of Jun loss promotes resistance to histone deacetylase inhibitor entinostat through Myc signaling in luminal breast cancer

by Maki Tanioka, Kevin R. Mott, Daniel P. Hollern, Cheng Fan, David B. Darr, Charles M. Perou
Published 2018-11-01

The MMTV-Wnt1 murine model produces two phenotypically distinct subtypes of mammary tumors with unique therapeutic responses to an EGFR inhibitor

by Adam D. Pfefferle, David B. Darr, Benjamin C. Calhoun, Kevin R. Mott, Jeffrey M. Rosen, Charles M. Perou
Published 2019-07-01

CD8α dendritic cells drive establishment of HSV-1 latency.

by Kevin R Mott, Sariah J Allen, Mandana Zandian, Bindu Konda, Behrooz G Sharifi, Clinton Jones, Steven L Wechsler, Terrence Town, Homayon Ghiasi
Published 2014-01-01

Inclusion of CD80 in HSV targets the recombinant virus to PD-L1 on DCs and allows productive infection and robust immune responses.

by Kevin R Mott, Sariah J Allen, Mandana Zandian, Omid Akbari, Pedram Hamrah, Hadi Maazi, Steven L Wechsler, Arlene H Sharpe, Gordon J Freeman, Homayon Ghiasi
Published 2014-01-01