Glycan modifications to the gp120 immunogens used in the RV144 vaccine trial improve binding to broadly neutralizing antibodies.

by Rachel C Doran, Gwen P Tatsuno, Sara M O'Rourke, Bin Yu, David L Alexander, Kathryn A Mesa, Phillip W Berman
Published 2018-01-01

Gene editing in CHO cells to prevent proteolysis and enhance glycosylation: Production of HIV envelope proteins as vaccine immunogens.

by Sophia W Li, Meredith Wright, John F Healey, Jennie M Hutchinson, Sara O'Rourke, Kathryn A Mesa, Pete Lollar, Phillip W Berman
Published 2020-01-01

Robotic selection for the rapid development of stable CHO cell lines for HIV vaccine production.

by Sara M O'Rourke, Gabriel Byrne, Gwen Tatsuno, Meredith Wright, Bin Yu, Kathryn A Mesa, Rachel C Doran, David Alexander, Phillip W Berman
Published 2018-01-01

Glycans flanking the hypervariable connecting peptide between the A and B strands of the V1/V2 domain of HIV-1 gp120 confer resistance to antibodies that neutralize CRF01_AE viruse...

by Sara M O'Rourke, Ruengpung Sutthent, Pham Phung, Kathryn A Mesa, Normand L Frigon, Briana To, Navin Horthongkham, Kay Limoli, Terri Wrin, Phillip W Berman
Published 2015-01-01

Unusual Cysteine Content in V1 Region of gp120 From an Elite Suppressor That Produces Broadly Neutralizing Antibodies

by Jennie M. Hutchinson, Kathryn A. Mesa, David L. Alexander, Bin Yu, Sara M. O'Rourke, Kay L. Limoli, Terri Wrin, Steven G. Deeks, Phillip W. Berman
Published 2019-05-01

Development of a Stable MGAT1− CHO Cell Line to Produce Clade C gp120 With Improved Binding to Broadly Neutralizing Antibodies

by Rachel C. Doran, Rachel C. Doran, Bin Yu, Meredith Wright, Sara M. O'Rourke, Lu Yin, Jennie M. Richardson, Gabriel Byrne, Kathryn A. Mesa, Phillip W. Berman
Published 2018-10-01

Ancestral sequences from an elite neutralizer proximal to the development of neutralization resistance as a potential source of HIV vaccine immunogens.

by Kathryn A Mesa, Bin Yu, Terri Wrin, Christos J Petropoulos, Grant H Pogson, David L Alexander, Gerardo Perez, Sara M O'Rourke, Faruk Sinangil, Joseph Robinson, Marcus A Conant, Phillip W Berman
Published 2019-01-01