Recent insights: mesenchymal stromal/stem cell therapy for acute respiratory distress syndrome [version 1; referees: 2 approved]

by Shahd Horie, John G. Laffey
Published 2016-06-01

Role of the adaptive immune response in sepsis

by Jack Brady, Shahd Horie, John G. Laffey
Published 2020-12-01

Modulating the distribution and fate of exogenously delivered MSCs to enhance therapeutic potential: knowns and unknowns

by Claire H. Masterson, Gerard F. Curley, John G. Laffey
Published 2019-07-01

Human Mesenchymal Stem Cell Secretome from Bone Marrow or Adipose-Derived Tissue Sources for Treatment of Hypoxia-Induced Pulmonary Epithelial Injury

by Nala Shologu, Michael Scully, John G. Laffey, Daniel O’Toole
Published 2018-09-01

The importance of discovery science in the development of therapies for the critically ill

by Nicole P. Juffermans, Peter Radermacher, John G. Laffey, on behalf of the Translational Biology Group
Published 2020-05-01

β-Glucans

by Emma J. Murphy, Emanuele Rezoagli, Ian Major, Neil Rowan, John G. Laffey
Published 2021-08-01

β-Glucan Metabolic and Immunomodulatory Properties and Potential for Clinical Application

by Emma J. Murphy, Emanuele Rezoagli, Ian Major, Neil J. Rowan, John G. Laffey
Published 2020-12-01

Cytokine pre-activation of cryopreserved xenogeneic-free human mesenchymal stromal cells enhances resolution and repair following ventilator-induced lung injury potentially via a K...

by Shahd Horie, Sean Gaynard, Mary Murphy, Frank Barry, Michael Scully, Daniel O’Toole, John G. Laffey
Published 2020-02-01

The interaction between arterial oxygenation and carbon dioxide and hospital mortality following out of hospital cardiac arrest: a cohort study

by Peter J. McGuigan, Manu Shankar-Hari, David A. Harrison, John G. Laffey, Danny F. McAuley
Published 2020-06-01

In vitro characterization of PrismaLung+: a novel ECCO2R device

by Ingeborg Hospach, Jacques Goldstein, Kai Harenski, John G. Laffey, Dominique Pouchoulin, Manuela Raible, Stefanie Votteler, Markus Storr
Published 2020-05-01

Death in hospital following ICU discharge: insights from the LUNG SAFE study

by Fabiana Madotto, Bairbre McNicholas, Emanuele Rezoagli, Tài Pham, John G. Laffey, Giacomo Bellani, the LUNG SAFE Investigators, the ESICM Trials Group
Published 2021-04-01

Embryonic-Derived <i>Myb</i>⁻ Macrophages Enhance Bacterial Clearance and Improve Survival in Rat Sepsis

by Mirjana Jerkic, Michael L. Litvack, Stéphane Gagnon, Gail Otulakowski, Haibo Zhang, Ori Rotstein, Brian P. Kavanagh, Martin Post, John G. Laffey
Published 2021-03-01

Overexpression of IL-10 Enhances the Efficacy of Human Umbilical-Cord-Derived Mesenchymal Stromal Cells in <i>E. coli</i> Pneumosepsis

by Mirjana Jerkic, Claire Masterson, Lindsay Ormesher, Stéphane Gagnon, Sakshi Goyal, Razieh Rabani, Gail Otulakowski, Haibo Zhang, Brian P. Kavanagh, John G. Laffey
Published 2019-06-01

Intra-vital imaging of mesenchymal stromal cell kinetics in the pulmonary vasculature during infection

by Claire H. Masterson, Arata Tabuchi, Grace Hogan, Glenn Fitzpatrick, Steven W. Kerrigan, Mirjana Jerkic, Wolfgang M. Kuebler, John G. Laffey, Gerard F. Curley
Published 2021-03-01

Umbilical Cord-Derived CD362⁺ Mesenchymal Stromal Cells Attenuate Polymicrobial Sepsis Induced by Caecal Ligation and Puncture

by Hector Gonzalez, Colm Keane, Claire H. Masterson, Shahd Horie, Stephen J. Elliman, Brendan D. Higgins, Michael Scully, John G. Laffey, Daniel O’Toole
Published 2020-11-01

High risk of patient self-inflicted lung injury in COVID-19 with frequently encountered spontaneous breathing patterns: a computational modelling study

by Liam Weaver, Anup Das, Sina Saffaran, Nadir Yehya, Timothy E. Scott, Marc Chikhani, John G. Laffey, Jonathan G. Hardman, Luigi Camporota, Declan G. Bates
Published 2021-07-01

Current therapies for gastro-oesophageal reflux in the setting of chronic lung disease: state of the art review

by Melissa J. McDonnell, Eoin B. Hunt, Chris Ward, Jeffrey P. Pearson, Daniel O'Toole, John G. Laffey, Desmond M. Murphy, Robert M. Rutherford
Published 2020-11-01

Epidemiology and patterns of tracheostomy practice in patients with acute respiratory distress syndrome in ICUs across 50 countries

by Toshikazu Abe, Fabiana Madotto, Tài Pham, Isao Nagata, Masatoshi Uchida, Nanako Tamiya, Kiyoyasu Kurahashi, Giacomo Bellani, John G. Laffey, for the LUNG-SAFE Investigators and the ESICM Trials Group
Published 2018-08-01

Umbilical cord-derived CD362+ mesenchymal stromal cells for E. coli pneumonia: impact of dose regimen, passage, cryopreservation, and antibiotic therapy

by Shahd Horie, Claire Masterson, Jack Brady, Paul Loftus, Emma Horan, Lisa O’Flynn, Steve Elliman, Frank Barry, Timothy O’Brien, John G. Laffey, Daniel O’Toole
Published 2020-03-01

Immunocompromised patients with acute respiratory distress syndrome: secondary analysis of the LUNG SAFE database

by Andrea Cortegiani, Fabiana Madotto, Cesare Gregoretti, Giacomo Bellani, John G. Laffey, Tai Pham, Frank Van Haren, Antonino Giarratano, Massimo Antonelli, Antonio Pesenti, Giacomo Grasselli, LUNG SAFE Investigators and the ESICM Trials Group
Published 2018-06-01