ELMO1 is upregulated in AML CD34+ stem/progenitor cells, mediates chemotaxis and predicts poor prognosis in normal karyotype AML.

by Marta E Capala, Edo Vellenga, Jan Jacob Schuringa
Published 2014-01-01

Convergence of hypoxia and TGFβ pathways on cell cycle regulation in human hematopoietic stem/progenitor cells.

by Albertus T J Wierenga, Edo Vellenga, Jan Jacob Schuringa
Published 2014-01-01

CombiFlow: Flow cytometry-based identification and characterization of genetically and functionally distinct AML subclones

by Roos Houtsma, Shanna M. Hogeling, Jan Jacob Schuringa
Published 2021-12-01

Modeling of Chronic Myeloid Leukemia: An Overview of In Vivo Murine and Human Xenograft Models

by Pallavi Sontakke, Jenny Jaques, Edo Vellenga, Jan Jacob Schuringa
Published 2016-01-01

Single-cell STAT5 signal transduction profiling in normal and leukemic stem and progenitor cell populations reveals highly distinct cytokine responses.

by Lina Han, Albertus T J Wierenga, Marjan Rozenveld-Geugien, Kim van de Lande, Edo Vellenga, Jan Jacob Schuringa
Published 2009-01-01

BRD3/4 inhibition and FLT3-ligand deprivation target pathways that are essential for the survival of human MLL-AF9+ leukemic cells.

by Marco Carretta, Annet Z Brouwers-Vos, Matthieu Bosman, Sarah J Horton, Joost H A Martens, Edo Vellenga, Jan Jacob Schuringa
Published 2017-01-01

Mitochondrial Dysfunction in Human Leukemic Stem/Progenitor Cells upon Loss of RAC2.

by Marta E Capala, Henny Maat, Francesco Bonardi, Vincent van den Boom, Jeroen Kuipers, Edo Vellenga, Ben N G Giepmans, Jan Jacob Schuringa
Published 2015-01-01

Hypoxia-Like Signatures Induced by BCR-ABL Potentially Alter the Glutamine Uptake for Maintaining Oxidative Phosphorylation.

by Pallavi Sontakke, Katarzyna M Koczula, Jennifer Jaques, Albertus T J Wierenga, Annet Z Brouwers-Vos, Maurien Pruis, Ulrich L Günther, Edo Vellenga, Jan Jacob Schuringa
Published 2016-01-01

Protein quality control in the nucleolus safeguards recovery of epigenetic regulators after heat shock

by Maria Azkanaz, Aida Rodríguez López, Bauke de Boer, Wouter Huiting, Pierre-Olivier Angrand, Edo Vellenga, Harm H Kampinga, Steven Bergink, Joost HA Martens, Jan Jacob Schuringa, Vincent van den Boom
Published 2019-06-01

HIF1/2-exerted control over glycolytic gene expression is not functionally relevant for glycolysis in human leukemic stem/progenitor cells

by Albertus T. J. Wierenga, Alan Cunningham, Ayşegül Erdem, Nuria Vilaplana Lopera, Annet Z. Brouwers-Vos, Maurien Pruis, André B. Mulder, Ulrich L. Günther, Joost H. A. Martens, Edo Vellenga, Jan Jacob Schuringa
Published 2019-12-01

The acute myeloid leukemia associated AML1-ETO fusion protein alters the transcriptome and cellular progression in a single-oncogene expressing in vitro induced pluripotent stem ce...

by Esther Tijchon, Guoqiang Yi, Amit Mandoli, Jos G A Smits, Francesco Ferrari, Branco M H Heuts, Falco Wijnen, Bowon Kim, Eva M Janssen-Megens, Jan Jacob Schuringa, Joost H A Martens
Published 2019-01-01

MLL5 improves ATRA driven differentiation and promotes xenotransplant engraftment in acute promyelocytic leukemia model

by Diego A. Pereira-Martins, Isabel Weinhäuser, Juan Luiz Coelho-Silva, Pedro L. França-Neto, Luciana Y. Almeida, Thiago M. Bianco, Cleide L. Silva, Rafael F. França, Fabiola Traina, Eduardo M. Rego, Jan Jacob Schuringa, Antonio R. Lucena-Araujo
Published 2021-04-01

Non-canonical PRC1.1 Targets Active Genes Independent of H3K27me3 and Is Essential for Leukemogenesis

by Vincent van den Boom, Henny Maat, Marjan Geugien, Aida Rodríguez López, Ana M. Sotoca, Jennifer Jaques, Annet Z. Brouwers-Vos, Fabrizia Fusetti, Richard W.J. Groen, Huipin Yuan, Anton C.M. Martens, Hendrik G. Stunnenberg, Edo Vellenga, Joost H.A. Martens, Jan Jacob Schuringa
Published 2016-01-01

The USP7-TRIM27 axis mediates non-canonical PRC1.1 function and is a druggable target in leukemia

by Henny Maat, Tjerk Jan Atsma, Shanna M. Hogeling, Aida Rodríguez López, Jennifer Jaques, Mirjam Olthuis, Marcel P. de Vries, Chantal Gravesteijn, Annet Z. Brouwers-Vos, Nisha van der Meer, Suzan Datema, Jonas Salzbrunn, Gerwin Huls, Roy Baas, Joost H.A. Martens, Vincent van den Boom, Jan Jacob Schuringa
Published 2021-05-01

Innovations, challenges, and minimal information for standardization of humanized mice

by Renata Stripecke, Christian Münz, Jan Jacob Schuringa, Karl‐Dimiter Bissig, Brian Soper, Terrence Meeham, Li‐Chin Yao, James P Di Santo, Michael Brehm, Estefania Rodriguez, Anja Kathrin Wege, Dominique Bonnet, Silvia Guionaud, Kristina E Howard, Scott Kitchen, Florian Klein, Kourosh Saeb‐Parsy, Johannes Sam, Amar Deep Sharma, Andreas Trumpp, Livio Trusolino, Carol Bult, Leonard Shultz
Published 2020-07-01

Reduced SLIT2 is Associated with Increased Cell Proliferation and Arsenic Trioxide Resistance in Acute Promyelocytic Leukemia

by Isabel Weinhäuser, Diego A. Pereira-Martins, Cesar Ortiz, Douglas R. Silveira, Luíse A. A. Simões, Thiago M. Bianco, Cleide L. Araujo, Luisa C. Koury, Raul A. M. Melo, Rosane I. Bittencourt, Katia Pagnano, Ricardo Pasquini, Elenaide C. Nunes, Evandro M. Fagundes, Ana B. Gloria, Fábio Kerbauy, Maria de Lourdes Chauffaille, Armand Keating, Martin S. Tallman, Raul C. Ribeiro, Richard Dillon, Arnold Ganser, Bob Löwenberg, Peter Valk, Francesco Lo-Coco, Miguel A. Sanz, Nancy Berliner, Emanuele Ammatuna, Antonio R. Lucena-Araujo, Jan Jacob Schuringa, Eduardo M. Rego
Published 2020-10-01

The Combination of Gefitinib With ATRA and ATO Induces Myeloid Differentiation in Acute Promyelocytic Leukemia Resistant Cells

by Luciana Yamamoto de Almeida, Luciana Yamamoto de Almeida, Diego A. Pereira-Martins, Diego A. Pereira-Martins, Diego A. Pereira-Martins, Isabel Weinhäuser, Isabel Weinhäuser, Isabel Weinhäuser, César Ortiz, César Ortiz, Larissa A. Cândido, Larissa A. Cândido, Ana Paula Lange, Nayara F. De Abreu, Sílvia E. S. Mendonza, Sílvia E. S. Mendonza, Virgínia M. de Deus Wagatsuma, Virgínia M. de Deus Wagatsuma, Mariane C. Do Nascimento, Mariane C. Do Nascimento, Helder H. Paiva, Helder H. Paiva, Raquel M. Alves-Paiva, Raquel M. Alves-Paiva, Camila C. O. M. Bonaldo, Daniele C. Nascimento, José C. Alves-Filho, Priscila S. Scheucher, Ana Sílvia G. Lima, Jan Jacob Schuringa, Emanuele Ammantuna, Tiziana Ottone, Tiziana Ottone, Tiziana Ottone, Nelida I. Noguera, Cleide L. Araujo, Eduardo M. Rego, Eduardo M. Rego, Eduardo M. Rego
Published 2021-09-01