The fitness landscape of HIV-1 gag: advanced modeling approaches and validation of model predictions by in vitro testing.

by Jaclyn K Mann, John P Barton, Andrew L Ferguson, Saleha Omarjee, Bruce D Walker, Arup Chakraborty, Thumbi Ndung'u
Published 2014-08-01

Subtype-specific differences in Gag-protease replication capacity of HIV-1 isolates from East and West Africa

by Omotayo Farinre, Kamini Gounder, Tarylee Reddy, Marcel Tongo, Jonathan Hare, Beth Chaplin, Jill Gilmour, Phyllis Kanki, Jaclyn K. Mann, Thumbi Ndung’u
Published 2021-05-01

High frequency of transmitted HIV-1 Gag HLA class I-driven immune escape variants but minimal immune selection over the first year of clade C infection.

by Kamini Gounder, Nagavelli Padayachi, Jaclyn K Mann, Mopo Radebe, Mammekwa Mokgoro, Mary van der Stok, Lungile Mkhize, Zenele Mncube, Manjeetha Jaggernath, Tarylee Reddy, Bruce D Walker, Thumbi Ndung'u
Published 2015-01-01

Variation in HIV-1 Nef function within and among viral subtypes reveals genetically separable antagonism of SERINC3 and SERINC5.

by Steven W Jin, Francis M Mwimanzi, Jaclyn K Mann, Mwebesa Bosco Bwana, Guinevere Q Lee, Chanson J Brumme, Peter W Hunt, Jeff N Martin, David R Bangsberg, Thumbi Ndung'u, Zabrina L Brumme, Mark A Brockman
Published 2020-09-01

Association between the cytokine storm, immune cell dynamics, and viral replicative capacity in hyperacute HIV infection

by Daniel M. Muema, Ngomu A. Akilimali, Okechukwu C. Ndumnego, Sipho S. Rasehlo, Raveshni Durgiah, Doty B.A. Ojwach, Nasreen Ismail, Mary Dong, Amber Moodley, Krista L. Dong, Zaza M. Ndhlovu, Jenniffer M. Mabuka, Bruce D. Walker, Jaclyn K. Mann, Thumbi Ndung’u
Published 2020-03-01

No evidence for selection of HIV-1 with enhanced gag-protease or Nef function among breakthrough infections in the CAPRISA 004 tenofovir microbicide trial.

by Denis R Chopera, Jaclyn K Mann, Philip Mwimanzi, Saleha Omarjee, Xiaomei T Kuang, Nonkululeko Ndabambi, Sarah Goodier, Eric Martin, Vivek Naranbhai, Salim Abdool Karim, Quarraisha Abdool Karim, Zabrina L Brumme, Thumbi Ndung'u, Carolyn Williamson, Mark A Brockman, CAPRISA 004 TRAPS Team
Published 2013-01-01

Selection of an HLA-C*03:04-Restricted HIV-1 p24 Gag Sequence Variant Is Associated with Viral Escape from KIR2DL3+ Natural Killer Cells: Data from an Observational Cohort in South...

by Angelique Hölzemer, Christina F Thobakgale, Camilo A Jimenez Cruz, Wilfredo F Garcia-Beltran, Jonathan M Carlson, Nienke H van Teijlingen, Jaclyn K Mann, Manjeetha Jaggernath, Seung-gu Kang, Christian Körner, Amy W Chung, Jamie L Schafer, David T Evans, Galit Alter, Bruce D Walker, Philip J Goulder, Mary Carrington, Pia Hartmann, Thomas Pertel, Ruhong Zhou, Thumbi Ndung'u, Marcus Altfeld
Published 2015-11-01